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Thread: Plaquenil

  1. #31
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    I have always my right eye with a strange sensation...like "bathed" !!! I'm not sure if it is Plaquenil effect but for be sure I've stopped to take this drug...bye
    male,laser treatments,no skincare utilized.

  2. #32
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    yes, it's hard to believe someone taking this drug for 3 weeks or something could have eye problems cause of it. I recommend you Pippo to contact eye specialist and not to worry. I had an appointment with eye specialist before starting with plaquenil and talked to him about the side effects. he said that it is well tolerated medicine, but to come back to routine checks in every year.

  3. #33
    Senior Member redhotoz's Avatar
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    Quote Originally Posted by coldbliss
    Count me out for Plaquenil. I don't like where this is headed. I read the side-effects of taking high dosages of this stuff. It's kind of frightening. I also think that rosacea sufferers tend to jump on the "latest" breakthrough bandwagon.

    Have there been in-depth medical studies completed with regards to Plaquenil treatments of rosacea (say in the past 3-5 years)? If not, then people who are taking this pill do not have enough information to make a decision to take these meds.

    The drug is used to combat rheumatoid arthritis and lupus. I just don't see how this fits with the treatment of rosacea.

    Third, people who suffer from meniere's disease, hearing loss, and tinnitus (persistent ringing in ears) should seriously avoid this medication. Anti-malarials are infamous for their ototoxicity levels.
    I agree about the possible negative side effects of anti-malarials. I was very cautious when I first read about this, so I did some more research into it...a lot actually!

    There has been mention of Tinnitus sufferers NOT taking this drug already and I agree with that wholeheartedly!

    As far as toxicity...toxic levels come about with an 'over dose' and corrected by stopping the drug immediately. Correct dosage of the drug correlating to body weight should not allow for an over dose. If any side effects to the negative are found, of course, the drug should be stopped immediately, as with any drug.

    There are no studies relating to Plaquenil and Rosacea that I have been able to find from 2000 to 2006. So this is a new idea for Rosacea sufferers.

    I am not about to jump in and start taking it but I have done my homework. I am also sitting back and waiting to hear from those on the Forum who are taking it now to see how they find it.

    The link with Lupus and RA comes up a lot in relation to Rosacea. Other than the obvious red "butterfly" cheeks symptoms of Lupus, I haven't done a lot of research on Lupus itself. But when it comes to RA, the link is being an inflammatory disorder...same as what I believe Rosacea is.

    As with anything read about or 'discovered' on this Forum, more info should be sort before making the decision to try that particular product. I always ask my Pharmacist, GP and maybe also my Derm before trying any medication! I hope everyone else does too!
    Currently trying: Apr 06 Bee Wilder's Candida (natural healing) Diet; May 06 Home made red LED array; Aug 06 ZZ ointment.

  4. #34
    Senior Member Miki's Avatar
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    where did you guys the plaquenil from? prescription from doctor? the web?

  5. #35
    Senior Member banshee's Avatar
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    Quote Originally Posted by redhotoz
    I have been searching for studies/case reports/research articles/general articles in dermatology journals on Plaquenil (Hydrochloroquine Sulfate) in relation to Rosacea.

    There were four studies quoted in the first thread, three pre 1966 and one with no date. These were not specifically in relation to Hydrochloroquine Sulfate, but to other anti-malarial medications – Triquin (a combination of 3 anti-malarials – not sure what they are); Mepacrine; Chloroquine and Resochin. I wasn't able to find a way to read these though because of their age.

    So, it appears that at this point in time, there is nothing to offer in that regard. Well nothing recent anyway from 2000 to 2006.

    Of the studies, case reports and articles I did come across, they were most prominently in relation to Rheumatoid Arthritis or Lupus (other than Malaria of course). What I have noticed of late (and because a friend of mine has RA) is that there are many similarities in what is prescribed/suggested for RA as is for Rosacea. The link I see here is inflammation.

    My resources are solely Internet web sites including the main ones www.medscape.com/homepage and www.pubmedcentral.gov as the library here is not worth considering! I did try but to no avail. If anyone else can find something then please, feel free! It’s arduous!

    Mum and Dad arrived today and I have some more reading to do now! Will post more when I have had time to go through it all.

    Will also check out Mapacrine but one step at a time!

    Red
    sorry it took a bit to get back to you....

    Thanks for collecting all this info...I'm kind bummed to hear folks believe it may be causing issues w/their eyes & that we can't find any case studies after the 1960's?? I'll have to reread Dr. Nase's post as I thought it sounded like his references were recent.

  6. #36
    Senior Member redhotoz's Avatar
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    Hi Banshee

    Here are the studies that were quoted in the original thread:

    "Four old studies of antimalarial treatment for rosacea. Very good results even with the older antimalarials.

    FREDRIKSSON T, LODIN A, ROSENGREN S.
    [Treatment of discoid lupus erythematosus, polymorphous photodermatosis and rosacea with Triquin--a combination of 3 anti-malarials.] Sven Lakartidn. 1962 Oct 4;59:2858-62. Swedish. No abstract available. PMID: 1395940233:

    BRODTHAGEN H. Related Articles, Links
    Mepacrine and chloroquine in the treatment of rosacea.
    Br J Dermatol. 1955 Dec;67(12):421-5. No abstract available.
    PMID: 13284197 [PubMed - OLDMEDLINE for Pre1966]

    34: RICHTER R, TAT L. Related Articles, Links
    [Studies on the treatment of rosacea with resochin.]
    Z Haut Geschlechtskr. 1955 Oct 1;19(7):211-5. German. No abstract available. PMID: 13282360 [PubMed - OLDMEDLINE for Pre1966]

    INMAN PM, GORDON B. Mepacrine in rosacea.
    Acta Derm Venereol. 1955;35(6):446-52. No abstract available.
    PMID: 13301319 [PubMed - OLDMEDLINE for Pre1966]"

    I think the confusion I had with these studies is that the copy and paste seemed to be a bit messy. So, have tidied them up to show the dates correctly...1962, 1955, 1955 & 1955. I think I have placed them correctly?

    Perry has promised to find the links to these studies. Pretty please Perry! I have searched and searched but to no avail. Maybe it is just the age of them, I don't know? I have created log-ins to medical web sites to search history but still can not locate them. Hey, I've stumbled across some fascinating stuff too!

    Although these studies are from over 40-50 years ago, as Brady stated in another thread, "Everything old is new again...", from 1878! So, it may be a starting point with these old studies. I just want to be able to read them!

    I am also going to embark on some research on Mepacrine, as suggested in this thread. Haven't had the time of late but will get to it as soon as I can.

    Just loving this research stuff! Dad thought none of his three daughters would ever take an interest in medicine, so we now have long chats on the phone about this drug and that. So, in some small way, this horrid Rosacea I have, has brought my Dad and I closer (albeit on the phone) and even just to talk about medical stuff. Hey, but it's nice when your Dad recognises that his blonde daughter has an analytical mind! LOL

    Red
    Currently trying: Apr 06 Bee Wilder's Candida (natural healing) Diet; May 06 Home made red LED array; Aug 06 ZZ ointment.

  7. #37
    Senior Member banshee's Avatar
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    Default re:Plaquenil

    once again thanks Reds

    I guess I'm a bit confused because Dr. Nase's post made it sound like this therapy has been showing results as of late. Or at least that's how I interpreted because how can one base a decision on case studies from the 60's. I assumed he was posting about now because there had been more collective evidence this was proving effective.

  8. #38
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    Hi Red,
    I did a pretty extensive search, and this is all I could find. My Keywords were "rosacea", "mepacrine" "chloroquine", and/or "anti-malarials".
    I don't think this is what you were seeking, but I tried.
    Perry

    Journals@Ovid Full Text Lazaridou, E; Sotiriadis, D; Ioannides, D; Chrysomallis, F Chloroquine in granulomatous rosacea. [Miscellaneous.]Journal of the European Academy of Dermatology & Venereology Supplement. 16 Supplement 1:117, September 2002.
    AN: 00147299-200209001-00657.

  9. #39
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    Does that mean that the study was conducted to see how it affected rosacea's p&p?
    I don't want to live with it. I refuse to.

  10. #40
    Senior Member redhotoz's Avatar
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    Quote Originally Posted by prryjones
    Hi Red,
    I did a pretty extensive search, and this is all I could find. My Keywords were "rosacea", "mepacrine" "chloroquine", and/or "anti-malarials".
    I don't think this is what you were seeking, but I tried.
    Perry

    Journals@Ovid Full Text Lazaridou, E; Sotiriadis, D; Ioannides, D; Chrysomallis, F Chloroquine in granulomatous rosacea. [Miscellaneous.]Journal of the European Academy of Dermatology & Venereology Supplement. 16 Supplement 1:117, September 2002.
    AN: 00147299-200209001-00657.
    Thanks Perry!

    I have spent hours upon hours trying to dig dig dig up anything recent on Rosacea linked with Plaquenil/anti-malarials. Nothing upon nothing comes up that has anything worth posting about!

    Even from the first post on Plaquenil, the original thread, Dr Nase typed out a report about using an antimalarial from someone. I thought it may have been from the "Pearls of Wisdom" he spoke of? This is what was he said in the original post:

    “You can find many of these treatments in "Peals of Wisdom" in Dermatology Clinics. One of the many Plaquenil reports on rosacea:

    Tackling Treatment Resistiant Rosacea -- Plaquenil comes to the Rescue

    A treatment resistant rosacea sufferer with severe redness, severe papules and severe burning has been treated by all the standard medications and laser treatments for 9 years without any improvement. The most amazing thing about the plaquenil is that my rosacea got significantly better. It's almost completely cleared without any other medication or maintenance treatment.. I don't feel like everyone's looking at my bright red, blotchy cheeks anymore. Both dermatologists are shocked. The redness is gone, the flushing is almost completely gone and the burning sensations have disappeard. I have had severe rosacea for 9 years. After 6 months of Plaquenil treatment I no longer have rosacea. I am now off Plaquenil for almost 3 years with no relapse.

    Dosage: 200 mg.
    Frequency: 2 tablets 1 x day
    Total Length: one year
    Brand: Hydroxychloroquine (generic)”

    I searched through other boards/forums to see if I could find someone who had used an anti-malarial for Rosacea. The closest I got was from this person rating the effect of Plaquenil on their cheek rash:

    "KRK (4) [Norfolk, VA - United States] 8/29/2003 7:16:22 PM
    Review PlaquenilI've been amazed at how much better I feel after a year on Plaquenil. Both the pain and fatigue are more manageable. I have fibromyalgia and antiphospholipid syndrome. I, supposedly, don't meet enough criteria for a lupus diagnosis; but, it's always in the back of my mind. I've had a malar rash for almost 10 years. The most amazing thing about the plaquenil is that my rash got significantly better. It's now more pinkish in hue than red. I don't feel like everyone's looking a my bright red, blotchy cheeks anymore. I feel more normal. Two different dermatologists said it was rosacea, but none of the medications for that ever did anything for me. Dosage: 200 mg.Frequency: 2 tablets 1 x dayTotal Length: one year Brand: Hydroxychloroquine (generic)"

    Link: http://www.remedyfind.com/review_lon...eview_id=10663

    The reports seem awfully similar but of course Geoffrey didn’t actually use quotation marks, so maybe he just typed out the bits he wanted us to read about this drug as “The Biggest Treatment Secret in Rosacea”?!

    So, Perry, you haven’t been able to find the 1955 x 3 and 1962 studies then? Blah! Guess it’s back to square one then! Why are these studies so hard to find? I have spent hours trying to find them! I used so many key words…from Rosacea to doctors names, dates etc.

    I just think I have spent way too much time trying to find things that…well..I don’t know…perhaps don’t exist???

    It all seems way too strange to me!

    Red
    Currently trying: Apr 06 Bee Wilder's Candida (natural healing) Diet; May 06 Home made red LED array; Aug 06 ZZ ointment.

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