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Thread: Compounding Pharmacists and Accutane

  1. #1
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    Default Compounding Pharmacists and Accutane

    Hello,

    I live in Australia and I was considering going on low to very low dose acctuane (perhaps somewhere between 2.5 - 5mg a day) but the lowest dose Accutane capsule you can get in Australia is 10mg.
    Therefore, I was thinking about going to see a compounding pharmacist to see if they could make a low dose Accutane capsule for me but I'm not sure if this is possible or not.

    If anyone has had any experience or knows anything about getting compounding pharmacists to make a low-dose Accutane capsule, I'd love to hear any information you might like to share on your experience.

    Thanks again - Trav

  2. #2
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    Trav, Why not just take a 10 mg. capsule every other day, or every 3rd day?? Why waste money when you don't have to, use the money to save up for IPL after you're done with the accutane.

  3. #3
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    Howdy,

    I thought about taking 10mg maybe once every 2 or 3 days but I remember reading a post that said taking 10mg once every 2 or 3 days was not the same as taking say 5mg every day.
    Even though you are only taking 10mg once every 2 or 3 days, you can still get some of the unwanted side effects as it will still metabolize in the body just the same as if you were taking the 10mg every day.

    I'm not too sure if I've explained myself properly but I think I'll still somehow try and get the lower dose 2.5 or 5mg capsules

    Thanks for your help - Trav

  4. #4
    Senior Member Mermaid's Avatar
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    Hi Trav,

    Recently Geoffrey posted the following info about splitting Accutane using a compounding pharmacy.

    He said:

    You can get this done at compounding pharmacies for a small fee (which actually ends up saving you money because if you get a script for 20 mg tablets, you can make it into four months of 5 mg tabs or eight months of 2.5 mg tabs). Make sure the compounding pharmacy has experience with accutane though and places it into an airtight capsule like accutane. Accutane is very sensitive to light and air and will be useless within a week or two if not properly prepared.

    Geoffrey
    ------------------------------------------------
    Dr. Geoffrey Nase
    Ph.D. Neuro-Vascular Physiologist
    Rosacea Research Specialist & Consultant
    http://www.drnase.com

    Hope this helps and you are quite right that taking a 10mg dose every 2-3 days, is not the same as taking 5mg daily due to spiking.

    Mermaid

  5. #5
    Senior Member irishgenes's Avatar
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    Do any of the isotretinoin brands come in pills or capsules? The only ones I have seen come in sealed soft gel caps. I would not think that many compounding pharmacists have anything but hard capsule and pill making equipment, but I haven't inquired. It just seems like they wouldn't have much use for a soft gel machine since so few drugs come like that. In the past, I have just stick a pin in the side of my Accutane soft gel caps and, depending on the strength, squeezed out a drop or more onto the pin. The soft gel cap "self heals" after you remove the pin, avoiding air and light getting into it. If anybody has had a compounding pharmacist make Accutane into smaller doses, I would like to know if the pharmacist required the doctor's OK and how much it cost.

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    Hi all,
    1)Take the capsule and soak in lukewarm water until it dissolves, leaving the inner orange "glob", floating on the surface. This is what you want. This is the "active ingredient". Again, as oil is lighter than water, it will float on the surface (the casule is water soluble so it dissolves in the gut).
    2)Put the container in the frig. until the orange "glob" becomes hard enough to "spoon" into a vacutainer tube. Transfer as little water as possible.
    3) Add the OIL of your choice (I have always used flaxseed oil) and mix.
    4) Serve yourself whatever dose increment you desire-eg- if you have mixed a 20mg "glob" with 10ml of Wesson Oil, then 25% would be approximately 5mg. Take with milk.
    5)Store room temp (and protected from light if desired)
    This formulation will be stable for a considerable time, but I usually make 1 weeks worth of dosing at a time.
    I repeat, this accutane-in-oil mixure will be stable. You will know this by realizing the consistent side effects that you have always had with isotretinoin-eg- dry lips, eyes, etc.
    Any questions, please ask,
    Perry

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    Hi Perry,

    Thanks so much for the info. I really appreciate it. I was just wondering if you might be able to tell me what a "vacutainer" is? Is it some sort of vacuum sealed container that I can buy at a shop / pharmacy?

    Another thing I was wondering if you could clarify for me was the part where you mentioned "mixing a 20mg glob with 10ml of Wesson Oil". Do you mean I should use the 10ml of Wesson Oil in addition to the flax oil I would have already mixed with it in the previous step?

    There doesn't happen to be a more detailed explanation of this anywhere online? Any extra info would be great.

    Thanks again - Trav

  8. #8
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    Hi Trav,
    Sorry for the confusion.
    A Vacutainer (brand) specimen collection tube is the type tube in which blood is drawn/collected (you know...when you go to a Dr. and you blood is drawn for lab tests).
    I am around that stuff all day, and sometimes in haste forget that some others aren't as familiar with that stuff. I didn't mean to be rude.
    Anyway...You can't buy them, but maybe you have a friend who works in healtcare that could obtain one for you?
    If not, any small container will do.
    My main point is that you want to dilute isotretinion with a suitable solvent in order to separate it out and formulate smaller doses. Sort of like dividing a pint into 4 quarts (4 gts in a pint, right??)
    So if you mix a 10mg accutane "glob" into 9 or 10ml of (any consumable oil -- I like to use flaxseed oil...but I would suggest any healthy oil...olive oil, etc. My use of Wesson was a very bad example. But any oil will do.), you will get a roughly 10ml dilution of accutane-oil forumulation that you can "spoon" to yourself in any dosing increment you desire. For example, if you want 5mg/day, then take half of the 10mg formulation. If you want 1mg/day, then spoon yourself approximately 10 percent of the 10ml formulation.
    A good help here would be to find a container that is marked with measured increments. This will make it easier to dose out your desired ammount.
    I use Vacutainer tubes bc I have access to them and have always worked with them. You can use anything you want, though.
    Hope I was more clear this time around.
    Perry

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    Hi Perry,

    Thanks so much for the extra information. I really appreciate it. Thanks again for clarifying those few things.

    Cheers - Trav

  10. #10
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    No prob Trav...good luck!
    Perry
    ps If you try this, please let us know how it turns out....

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