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Thread: Sans Rosa patient cases

  1. #1
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    Default Sans Rosa patient cases

    It is very exciting to read these patient cases about Sans Rosa. I wish it would come out today...

    [0104] Subject 1 is a 59 year old woman with a ten year history of rosacea displaying symptoms of periodic redness flare-ups across her cheeks that usually runs a course of three to four weeks before subsiding under customary dermatological treatment. The subject showed an immediate improvement after the first morning application of Alphagan-P. All redness disappeared within 10 minutes and her face remained symptom free for the entire first day. Daily observation showed only mild return of redness after 24 hours. Continued daily use resulted in completely eliminating the redness due to rosacea in three days.

    [0105] Subject 2 is a 54 year-old woman with an eight year history of rosacea who suffers from everyday facial redness across her cheeks with occasional severe flare-ups. The subject halted her customary daily dermatological treatment to try the protocol described above. The result was the same immediate removal of all redness within ten minutes. The dramatic improvement lasted most of the day with some mild redness re-occurring in the evening. For this subject, redness returned the next day. Continued daily use provided daily relief from redness.

    [0106] Subject 3 is a 57 year-old man with a greater than ten-year history of rosacea displaying symptoms of redness of the cheeks and the nose. Although this subject's redness due to rosacea is always present, his general ruddy complexion and lack of concern allows him to forgo the daily use of customary dermatological treatment in favor of occasional, ad hoc treatments. A single morning trial of the Alphagan-P protocol described above resulted in dramatic daylong relief of redness.

    [0107] Subject 4 is a woman in her early forties with a diagnosis of rosacea on her lower face and chin. Her condition includes some thickening of skin. Upon trying the protocol, redness was greatly reduced but not completely eliminated. Qualitatively the reduction was described as 80% less red. An additional observation of reduced skin thickening was reported.

    [0108] These trials demonstrate that 0.15% brimonidine tartrate, when used in a daily morning protocol, dramatically eliminates or reduces redness due to rosacea. It is shown to be an effective treatment to greatly accelerate the arrest of a rosacea flare-up. It is further shown to be an effective daily treatment for chronic rosacea redness.

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    hey mate,


    where did you get the info, does it say anything about other rosacea factors such as stinging, burning e.t.c or is it strictly a redness thing. Aswell, is it still 2 years away.................................

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    Wow, it really does sound like it does what it says on the tin, so to speak.
    Hopefully this will make market without too many issues. Im counting the days!

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    Yeh i kno, if they r getting these results already, it seems a shame if we have to wait another 2 yrs....

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    Bob,

    They just finished a 28 day split face study with these impressive results.

    The main concerns where:

    1. Rebound dilation -- did not happen. The rosacea returned in some cases after 24 hours, but it did not rebound to a "twice as red face".

    2. Keeping enough tonic blood flow to supply oxygen and nutrients -- it did.

    3. Effect on the facial skin's immune system -- it should not have any effect because it is selective for alpha-2 adrenergic receptors

    4. High vascularity bringing medication into brain vessels -- very low concentration absorbed systemically, so this is probably out.

    I tried to fit these case studies into my Dermatology Times article but with the space limitation I thought it was better to discuss multiple drugs. This is one you can put on your shelf.

    It is my understanding that the approval will be MUCH faster through the FDA because this medication (or a derivative of it) has been used long term in humans on the eye (one of the most dangerous places to put any topical on and one of the slowest approval routes to make sure no damage is done to the eye). This figures to cut the red tape in half, but the next step is a large multicenter study which is in the mix. Thanks for the info. articolbo.

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    Well, what can I say... other than bonza! I look forward to further good news.

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    I wonder: if your skin is too sensitive for any toppical (till now) like mine, could this new med still be benificial or do you first need to make the skin less sensitive and overreactive? Even the mildest of the mildest toppical is unbearable for me and I know for some others.

    Thanks Natalja

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    So if like me, you have a pale face in the morn and then much more susceptability to flush later in the afternoon/evening, would you still apply this stuff every morn or would it be a case of using it as and when you feel a flush coming?

    I agree i wish this stuff was coming out soon. Is it around two years we have to wait?

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    Wow, sounds promising. Litteraly cant wait! Would be a shame if this medicine did not pass FDA and never came into the market!

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