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Thread: Clonidine not working

  1. #1
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    Default Clonidine not working

    I was prescribed doxycycline, rosex and clonidine for my rosacea by a derm. The first few days it seemed to be working great but just over a week later I now have extrenely painful red cheeks and nose again
    .

    Should clonidine work as soon as you start taking it or does it take time? I can't live with this. I lost my job and everything.

  2. #2
    Senior Member Brady Barrows's Avatar
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    Assuming that your dermatologist prescribed the clonidine for flushing, there is evidence it should help you in avoiding flushing. It does absolutely nothing for rosacea flareups (there is a difference between flushing and a rosacea flareup). It appears that your dermatologist is old school to prescribe Rozex and doxycycline for your rosacea. Did he actually diagnose you with rosacea or did he diagnose you with acne? Did he mention what subtype you have or did he mention what phenotype? Old school dermatologists continue to refer to subtypes while those who are keeping up with rosacea latest information are using phenotypes. So let's discuss each drug prescription one at a time.

    Clonidine is used to treat high blood pressure, attention deficit hyperactivity disorder, drug withdrawal (alcohol, opioids, or smoking), menopausal flushing, diarrhea, and certain pain conditions. It is NOT used to treat rosacea (as mentioned, probably your physician is using it to avoid flushing or you may have another diagnosis for using clonidine). It is used by mouth, by injection, or as a skin patch. Onset of action is typically within an hour with the effects on blood pressure lasting for up to eight hours. Common side effect include dry mouth, dizziness, headaches, and sleepiness. Severe side effects may include seeing or hearing things that other people do not, heart arrhythmias, and confusion. If rapidly stopped, withdrawal effects may occur. Since your physician probably prescribed this for your flushing (an assumption), did you notice improvement in a reduction of your flushing episodes? That would probably be the only reason he prescribed it since it will do absolutely nothing in preventing a rosacea flareup. Did he give you another diagnosis besides your skin issue?

    Rozex is metronidazole. If you are allergic to metronidazole or any of the other ingredients of this medicine this can be an issue. An allergic reaction may include a rash or itching. For example, Rozex Cream contains cetostearyl alcohol Cetostearyl alcohol may cause local skin reactions (e.g. contact dermatitis). Usually, a skin patch test is done, i.e., inside of your wrist, to see if you are allergic to Rozex. it usually takes a month to see improvement with metronidazole treatment for rosacea. It is not immediate improvement. Metronidazole has been used to treat rosacea for over fifty years and used to be the 'gold standard' treatment along with doxycycline to treat rosacea. However, that is old school treatment, the new gold standard is ivermectin (Soolantra) and doxycycline.

    Doxycycline has been used to treat rosacea as part of the 'gold standard' for many, many years. Before this tetracycline was the gold standard. Doxycycline is tetracycline-class broad spectrum antibiotic, meaning it is a derivative of tetracycline. High dose doxycycline has been used for many, many years. Probably your old school dermatologist prescribed high dose, i.e., 100 mg twice a day or possibly even higher. This usually improves rosacea flareups within a month but takes probably two to three months for most rosaceans, and four to six months for clearance. The new gold standard is low dose doxycycline, i.e., 30 mg of immediate release and 10 mg of delayed release (Oracea), or simply using generic doxycycline 20 mg twice a day. It takes time for doxycycline to work, usually at least a month to notice improvement.

    The only way to know if your old school treatment works is to keep using it for at least a month and you should see some improvement. There is no IMMEDIATE treatment for rosacea that clears you up in several days. You should know if the clonidine is working to avoid your flushing immediately but your rosacea flareups remain. There are a huge number of treatments to avoid flushing which you may consider if the clonidine isn't improving your flushing avoidance.
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    Quote Originally Posted by Brady Barrows View Post
    Assuming that your dermatologist prescribed the clonidine for flushing, there is evidence it should help you in avoiding flushing. It does absolutely nothing for rosacea flareups (there is a difference between flushing and a rosacea flareup). It appears that your dermatologist is old school to prescribe Rozex and doxycycline for your rosacea. Did he actually diagnose you with rosacea or did he diagnose you with acne? Did he mention what subtype you have or did he mention what phenotype? Old school dermatologists continue to refer to subtypes while those who are keeping up with rosacea latest information are using phenotypes. So let's discuss each drug prescription one at a time.

    Clonidine is used to treat high blood pressure, attention deficit hyperactivity disorder, drug withdrawal (alcohol, opioids, or smoking), menopausal flushing, diarrhea, and certain pain conditions. It is NOT used to treat rosacea (as mentioned, probably your physician is using it to avoid flushing or you may have another diagnosis for using clonidine). It is used by mouth, by injection, or as a skin patch. Onset of action is typically within an hour with the effects on blood pressure lasting for up to eight hours. Common side effect include dry mouth, dizziness, headaches, and sleepiness. Severe side effects may include seeing or hearing things that other people do not, heart arrhythmias, and confusion. If rapidly stopped, withdrawal effects may occur. Since your physician probably prescribed this for your flushing (an assumption), did you notice improvement in a reduction of your flushing episodes? That would probably be the only reason he prescribed it since it will do absolutely nothing in preventing a rosacea flareup. Did he give you another diagnosis besides your skin issue?

    Rozex is metronidazole. If you are allergic to metronidazole or any of the other ingredients of this medicine this can be an issue. An allergic reaction may include a rash or itching. For example, Rozex Cream contains cetostearyl alcohol Cetostearyl alcohol may cause local skin reactions (e.g. contact dermatitis). Usually, a skin patch test is done, i.e., inside of your wrist, to see if you are allergic to Rozex. it usually takes a month to see improvement with metronidazole treatment for rosacea. It is not immediate improvement. Metronidazole has been used to treat rosacea for over fifty years and used to be the 'gold standard' treatment along with doxycycline to treat rosacea. However, that is old school treatment, the new gold standard is ivermectin (Soolantra) and doxycycline.

    Doxycycline has been used to treat rosacea as part of the 'gold standard' for many, many years. Before this tetracycline was the gold standard. Doxycycline is tetracycline-class broad spectrum antibiotic, meaning it is a derivative of tetracycline. High dose doxycycline has been used for many, many years. Probably your old school dermatologist prescribed high dose, i.e., 100 mg twice a day or possibly even higher. This usually improves rosacea flareups within a month but takes probably two to three months for most rosaceans, and four to six months for clearance. The new gold standard is low dose doxycycline, i.e., 30 mg of immediate release and 10 mg of delayed release (Oracea), or simply using generic doxycycline 20 mg twice a day. It takes time for doxycycline to work, usually at least a month to notice improvement.

    The only way to know if your old school treatment works is to keep using it for at least a month and you should see some improvement. There is no IMMEDIATE treatment for rosacea that clears you up in several days. You should know if the clonidine is working to avoid your flushing immediately but your rosacea flareups remain. There are a huge number of treatments to avoid flushing which you may consider if the clonidine isn't improving your flushing avoidance.
    SHE gave me it to help with flushing. Strangely it hasn't helped with flushing yet but it almost immediately reduced my redness...

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    Quote Originally Posted by Sineadrosy View Post
    SHE gave me it to help with flushing. Strangely it hasn't helped with flushing yet but it almost immediately reduced my redness...
    Clonidine can help with the redness and flushing, though not with pustules and papules. But it can improve the appearance of skin lesions simply by taking some of the redness out of these flare ups. However, clonidine is not very effective. Moxonodine is a more modern effective alpha blocker - the same type of medicine. In the UK, you can get prescribed moxonodine - though it can be harder to get in America. There are certainly a lot of other medicines that can help if the current regime is not sufficient - e.g. hydroxychloroquine, mepacrine, propranolol, mirtazapine, gabapentin etc. It is worth finding a dermatologist who is really expert in using different medications to treat rosacea - many only use a very small number of the possible options which may not work best for you.

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    Quote Originally Posted by antwantsclear View Post
    Clonidine can help with the redness and flushing, though not with pustules and papules. But it can improve the appearance of skin lesions simply by taking some of the redness out of these flare ups. However, clonidine is not very effective. Moxonodine is a more modern effective alpha blocker - the same type of medicine. In the UK, you can get prescribed moxonodine - though it can be harder to get in America. There are certainly a lot of other medicines that can help if the current regime is not sufficient - e.g. hydroxychloroquine, mepacrine, propranolol, mirtazapine, gabapentin etc. It is worth finding a dermatologist who is really expert in using different medications to treat rosacea - many only use a very small number of the possible options which may not work best for you.
    Dies clonidine take time or should it work as soon as y start using it?

  6. #6
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    Quote Originally Posted by Sineadrosy View Post
    Dies clonidine take time or should it work as soon as y start using it?
    "Onset of action is typically within an hour with the effects on blood pressure lasting for up to eight hours." Source
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    Quote Originally Posted by Brady Barrows View Post
    "Onset of action is typically within an hour with the effects on blood pressure lasting for up to eight hours." Source
    It's just not working for me at all. I am a lost cause.

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    Quote Originally Posted by Sineadrosy View Post
    It's just not working for me at all. I am a lost cause.
    You?re not a lost cause Sineadrosy. If it?s not working, it?s because you don?t have flushing per se, it?s because you have a burning nerve pain. It needs nerve pain relief. Get to your gp asap.

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    Senior Member Brady Barrows's Avatar
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    Quote Originally Posted by Sineadrosy View Post
    It's just not working for me at all. I am a lost cause.
    Sineadrosy,
    You are NOT a lost cause. What works for one rosacean may or may not work for another. This has been dubbed the Rosacea X-Factor which has been around for over twenty years! Finding a rosacea treatment that actually works the first round of treatment is a dream come true but for most rosaceans it takes multiple rounds of different treatments until you find what works for Sineadrosy. And when you do find what works for you, wouldn't it be nice to post your treatment regimen so that other rosaceans in the same boat as you are now try your treatment and it works for them? That is why RF has been around for so long and why there are so many in the rosacea social media groups asking the same questions about what works to treat rosacea since many of the standard treatments simply don't work for them. You may find this post helps you in your personal investigation.

    For example, I have heard about azelaic acid since 2007 but have never tried it. My dermatologist asked me about it and recommend I try it. I am trying it now for about a month and am impressed with the results. I will continue using azelaic acid for a couple more months and am posting updates in my rosacea blog.
    Last edited by Brady Barrows; 25th September 2020 at 12:46 AM.
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    Clonidine is not a very effective modern drug to treat blood pressure issues. That's why I suggested some more effective drugs above. Clonidine does start working quickly, but its effect usually wears off anyway after a few months. Whether clonidine works or not for you is not an answer as to whether there is good treatment available, because clonidine is ineffective for most people in the medium to long term anyway.

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