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Thread: Accutane has cured my flushing

  1. #11
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    Quote Originally Posted by patrick33 View Post

    The only thing I don't understand is how this has worked, I've been looking at lots of research about ultra low dose Isotretinoin and, the only thing I have come up with is that at low dose it can normalize the immune response of exaggerated toll like receptors (tlr2).
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614089

    The above was for acne but it says about Isotretinoin:
    "Treatment of patients with isotretinoin significantly decreased monocyte TLR-2 expression and subsequent inflammatory cytokine response.. This effect was sustained six months following cessation of therapy, indicating that TLR-2 modulation may be involved in the durable therapeutic response to isotretinoin.
    The modulation of TLR-2 expression on monocytes has important implications in other inflammatory disorders characterized by TLR-2 dysregulation."

    If you can find a dose low enough that doesn't aggravate redness or flushing it can help down-regulate and normalize TLR-2 expression (TLR-2 is indicated in the pathogenesis or Rosacea). That might be how it helped you.

  2. #12
    Senior Member Brady Barrows's Avatar
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    Quote Originally Posted by Mknlvi View Post
    It would be interesting to find out what doses of Isotretinoin others have taken for Rosacea on this forum when it didn't help them. Search isn't bring up much on doses as low as 2.5mg a day.
    Wouldn't it be incredible to unite rosaceans together into one non profit organization so that they could engage in this type of research with confirmed followup reports on those who say rosacea remission has actually been sustained for six months, one year, two years, five years?
    Brady Barrows
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  3. #13
    Senior Member Brady Barrows's Avatar
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    Thanks for the link. I have added it to the Cytokines and Rosacea post.
    Brady Barrows
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