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Thread: Artemisinin, a potential option to inhibit inflammation and angiogenesis in rosacea

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    Default Artemisinin, a potential option to inhibit inflammation and angiogenesis in rosacea

    Highlights

    ART attenuated rosacea-like dermatitis in LL37-induced mouse model.


    ART reduced the expression of proinflammatory factors and infiltration of inflammation cells in LL37-induced rosacea-like mouse.


    ART repressed pro-inflammatory factors release in HaCaT cells may partly via NF-kB signal pathways.


    ART inhibited angiogenesis in vivo and migration of HUVECs in vitro.


    https://www.sciencedirect.com/scienc...53332219310339

    Apparently the herb wormwood contains Artemisinin I think, although I did not read up thoroughly on that. Interesting nonetheless.

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    Default Found another link to artesunate

    Not sure if they are the same or similar compound, perhaps this has been discussed about before. Would be interesting to know the dosing and whether it is as effective as doxycycline without the sideffects


    https://www.ncbi.nlm.nih.gov/pubmed/29693177

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    You cab buy supplement versions of Artemisia annua, also known as sweet wormwood . People buy them for malaria. I don't know how effective they compare to Artemisinin but they are the same substance.

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    Wormwood is supposed to help treat b. hominis infection. Did you manage to treat that ok?

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    Quote Originally Posted by antwantsclear View Post
    Wormwood is supposed to help treat b. hominis infection. Did you manage to treat that ok?
    Sadly not I still have the infection and seems impossible to remove the parasites... although there is a doctor who does an antibiotic infusion in Australia. It looks likely I will have to live with them. It would interesting to know if Woodworm has helped anyone with rosacea at all. Difficult to know what the dosing is though and I think you have to be careful with wormwood.

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    Quote Originally Posted by Dan3dwards View Post
    Not sure if they are the same or similar compound, perhaps this has been discussed about before. Would be interesting to know the dosing and whether it is as effective as doxycycline without the sideffects
    https://www.ncbi.nlm.nih.gov/pubmed/29693177
    "Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection." DrugBank

    Artesunate is a prescription treatment while artemisinin is available non prescription. Both are anti-parasitic treatments used for rosacea.
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    Quote Originally Posted by Dan3dwards View Post
    Not sure if they are the same or similar compound, perhaps this has been discussed about before. Would be interesting to know the dosing and whether it is as effective as doxycycline without the sideffects


    https://www.ncbi.nlm.nih.gov/pubmed/29693177
    Interesting, a doc suggested a JAK/STAT inhibitor (tofacitinib) for me. It might be a little different from the ones mentioned though (not sure) and he has not used it in other patients like me. Another doc thought it could help target some molecules that are probably involved in my flushing/burning but another doc was less enthusiastic, saying it would probably be better in granulomatous conditions.

    I did order some artemesia online recently, and just coincidentally saw this post.
    Last edited by laser_cat; 21st April 2020 at 02:40 AM.

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    I've tried taking sweet wormwood extract but not consistently. When I do, I notice an immediate relief in swelling / tightness of my face. For me it is more potent than plaquenil (which doesn't do much for me). Feels sort of anti-inflammatory like an antibiotic. (also gives me the same dizziness / brain fog as an antibiotic).

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    Quote Originally Posted by laser_cat View Post
    I've tried taking sweet wormwood extract but not consistently. When I do, I notice an immediate relief in swelling / tightness of my face. For me it is more potent than plaquenil (which doesn't do much for me). Feels sort of anti-inflammatory like an antibiotic. (also gives me the same dizziness / brain fog as an antibiotic).
    I have been looking to try this but can't find anything that looks like it will work on amazon. Do you remember what dose you used or brand (tablet, powder?).

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    Senior Member Brady Barrows's Avatar
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    Quote Originally Posted by Johndlwdbm View Post
    I have been looking to try this but can't find anything that looks like it will work on amazon. Do you remember what dose you used or brand (tablet, powder?).
    Quote Originally Posted by Brady Barrows View Post
    "Artesunate is part of the artemisinin group of drugs that treat malaria. It is a semi-synthetic derivative of artemisinin that is water-soluble and may therefore be given by injection." DrugBank

    Artesunate is a prescription treatment while artemisinin is available non prescription. Both are anti-parasitic treatments used for rosacea.
    Quote Originally Posted by Johndlwdbm View Post
    It seems impossible to buy this in the UK. Looking at the amazon USA website it is sold as a health supplement by many big-brands and easy to get as tablets. Nothing in the UK, I wonder if it is banned. Also are the health supplements tablets in the USA the same thing as the prescription drug called Artemisinin??
    That is too bad it isn't available in the UK through Amazon. You might ask a seller in the USA if shipments to the UK are available which will obviously cost you more. Non prescription artemisinin is obviously less strength than prescription artemisinin.
    Last edited by Brady Barrows; 9th June 2020 at 02:40 AM.
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