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Thread: Rhofade good for at least a year and gentler than Mirvaso

  1. #1

    Default Rhofade good for at least a year and gentler than Mirvaso

    Rhofade good for at least a year and gentler than Mirvaso


    If you decide to try Allerganís topical for redness Ė Rhofade, is it likely to work for you, and how long should you expect it to continue to work for you?
    Well, a year long study of users of Rhofade has found that the vast majority continued to enjoy ongoing significant relief from their facial redness for at least a year.
    Here is everything you need to know about using Rhofade long term.


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  2. #2
    Senior Member Brady Barrows's Avatar
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    Thanks Dave for all the work in putting this together. Are you using Rhofade? What exactly is your current regimen for treating your rosacea?
    Brady Barrows
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  3. #3
    Senior Member laser_cat's Avatar
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    Just pulling this quote out for others; a clear explanation on the differences between rhofade / mirvaso in terms of mechanism of action

    "Persistent facial erythema involves a complex pathophysiology of neurovascular dysregulation, enhanced immune response, and alteration of the cutaneous vasculature.15 Modifications in the superficial cutaneous vasculature are regulated primarily by the sympathetic nervous system.15, 16, 17 Oxymetazoline causes vasoconstriction primarily by activating α1A-adrenoceptors; conversely, brimonidine (Mirvaso, Galderma Laboratories, Fort Worth, TX), which is another treatment for persistent erythema of rosacea, causes vasoconstriction through α2-adrenoceptors.11, 12, 15, 18 Vascular smooth muscle cells express α1-adrenoceptors postsynaptically; thus, activation by an α-adrenoceptor agonist results in vasoconstriction.16 In contrast, α2-adrenoceptors may be expressed presynaptically and/or postsynaptically, depending on vessel type.16, 17 Activation of postsynaptic α2-adrenoceptors in the vascular smooth muscle causes vasoconstriction, but activation of presynaptic α2-adrenoceptors or α2-adrenoceptors in the vascular endothelium results in vasodilation, which may counteract the vasoconstrictor effect. Differences in mechanism of action between oxymetazoline, an α1A-adrenoceptor agonist,11, 12 and brimonidine, a selective α2-adrenoceptor agonist,18 may contribute to differences in their safety profiles observed in the respective long-term safety studies.19"

    (perhaps a helpful visual for this - https://www.cvpharmacology.com/vasoc.../alpha-agonist )

    I'm personally surprised of the low rate of rebound. I would think rhofade would be similar to sudafed (which also acts on the alpha adrenergic receptors causing vasoconstriction) and afrin (same active ingredient as rhofade), in that repeated use causes rebound congestion/swelling/vasodilation. Maybe the lining of the nasal passages is just a different can of worms than the facial skin.

    It would be interesting to see a similar year-long study on how rhofade gets along with "flushers" (as opposed to persistent redness). As well as topical timolol / beta blockers!

    PS Really find your rosacea site very informative David, thanks
    Last edited by laser_cat; 9th July 2018 at 08:08 PM.

  4. #4

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    Quote Originally Posted by laser_cat View Post

    PS Really find your rosacea site very informative David, thanks
    Thanks! Appreciate the feedback.
    Get Rosacea News here - https://rosacea-support.org

  5. #5
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    Does anyone in here use rhofade? Would like to know what type of success they have but if it did it will require you to use it forever to continue success.

  6. #6
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    Never mind I just was reading some of the testimonials and it has a horrible success rate. Look like another fail! 😭

  7. #7

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    It seems though, that Rhofade is getting better reviews overall compared to Mirvaso. So you might expect better results with Rhofade.

    One of the interesting things about this long term study is that it quantifies how likely you are to get a benefit and how likely to get a negative reaction.

    See Rhofade User Reviews for some more reviews.
    Get Rosacea News here - https://rosacea-support.org

  8. #8
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    Had terrible rebound redness with rhofade. How is this considered a good solution?

  9. #9

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    Only considered a good solution for those whom it worked for of course.
    Get Rosacea News here - https://rosacea-support.org

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