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Thread: KPRF, LRP-1 and Metalloproteinases

  1. #41
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    Quote Originally Posted by ggk2311@yahoo.com View Post
    I sware he's the most ignorant , negative and bitter person I've ever came across
    You live in Ireland .. lets meet up and say that to my face . Last thing you will ever say you little ****

  2. #42
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    Quote Originally Posted by davekelly View Post
    You live in Ireland .. lets meet up and say that to my face . Last thing you will ever say you little ****
    Believe me id love to say it to your face. I'm 6ft 3 so I'm not all that little mate ... But I'd gladly meet up with you to find out why the **** your so negative !!!!

  3. #43
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    Quote Originally Posted by Xxcooperxx View Post
    Just keeping the thread updated as I said I would, taking 2 capsules in morning and 2 in afternoon, I can see alittle improvement already, not had one flush yet and redness is more tolerable, that's an honest updated, will see how things are by end of week don't want get my hopes up yet...
    1 caps = how many mg Ashwangahas root?

  4. #44
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    Quote Originally Posted by poppe View Post
    1 caps = how many mg Ashwangahas root?
    450 mg

  5. #45
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    Quote Originally Posted by davekelly View Post
    Get your hopes up for what ? . You are living in fantasy land if you think anything good is going to come from this .
    Could be right Dave, but I'm willing try stuff when someone has a good theory behind the idea, if it dosent do nothing then nothing's loss..!

  6. #46
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    Quote Originally Posted by Xxcooperxx View Post
    Could be right Dave, but I'm willing try stuff when someone has a good theory behind the idea, if it dosent do nothing then nothing's loss..!
    Reason I said that because it caused Mistica to Flush terribly . And that's good enough for me mate .

    Trust me Mistica knows what she's talking about .

  7. #47
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    Quote Originally Posted by davekelly View Post
    Reason I said that because it caused Mistica to Flush terribly . And that's good enough for me mate .

    Trust me Mistica knows what she's talking about .
    That's fair enough, but she did say she hasn't KPRF which the thread started was the link between KPRF and possibly faulty LPR-1, I hold my hands up and say I don't totally understand it, but ashwagandha apparently can help the LPR-1, that's the reason I'm trying it Dave, and in all honesty today I was quite surprised when I kept checking how my face was when working I wasn't glowing red like usual that's the honest truth...

  8. #48
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    Quote Originally Posted by Xxcooperxx View Post
    That's fair enough, but she did say she hasn't KPRF which the thread started was the link between KPRF and possibly faulty LPR-1, I hold my hands up and say I don't totally understand it, but ashwagandha apparently can help the LPR-1, that's the reason I'm trying it Dave, and in all honesty today I was quite surprised when I kept checking how my face was when working I wasn't glowing red like usual that's the honest truth...
    Either can I mate

    This is what I cant get my head around with this . So is the LPR -1 link responsible for the flushing or the red cheeks ?

    Because constant flushing gave me red cheeks . and its the other way around for others . They just have red cheeks but no flushing

    KPRF = Red Cheeks only

    KPRF2 = Red Cheeks and Flushing (caused by Heated rooms ,Sun ,Alcohol, Sugar food + drinks, Excitement , Stress )

    I take it you are KPRF2 . That's what I am
    Last edited by davekelly; 22nd February 2016 at 10:42 PM.

  9. #49
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    Quote Originally Posted by davekelly View Post
    Reason I said that because it caused Mistica to Flush terribly . And that's good enough for me mate .

    Trust me Mistica knows what she's talking about .
    It is nice of you to consider my experiences and posts valid, but at the end of the day, we are individuals.
    My intention when I post is to provide as much information as I can in the form of science related stuff given to me by my friendly scientist mentors and about my personal syndrome. Things that make me flush. Other health issues that I have, so that other members can determine if their particular syndrome, triggers closely matches mine thus far. If it does, there is an increased chance that the same drugs/supplements will produce the same reaction.
    Extreme flushing can cause more vascular abnormalities. It doesn't just bound back to the previous state. I am always keen to help people avoid getting worse.
    I've undertaken a lot of experiments, some of them well planned and some of them foolish.
    Whilst KP and rosacea flushing present differently, there does seem to be some common features.

    Ashwagandha is a much favoured herb in Ayurvedic healing. It's been around since ancient times and is known for it's restorative powers.
    It is known as an adaptogen.

    http://www.smart-publications.com/ar...heart-and-mind

    As can be seen in the above uses, it has many effects, including modification of mood.
    It can acts much like a mild antidepressant, anti anxiety drug.
    Thus it affects the CNS. It could be, that xxcoooperxx is benefiting from these effects. There is no way of knowing if his improvements are due to the ability of ashwagandha to modify the LPR-1 receptor. It could be it is doing that. It could be doing that and modifying nerve firing at the same time. It might be doing both, or something else completely.
    I don't know. If I had to lay a bet, I'd say, irrespective of all other properties, it is likely having CNS affects.

    This isn't necessarily a bad effect. If it is reducing symptoms without producing negative side effects, that is a positive. Perhaps the package deal of varied effects will eventually induce a state of improved function in the skin/veins?
    Keep in mind, that stopping the herb, may produce withdrawal in the form of anxiety etc. I have seen that in reviews by some other users.

    Antidepressants and anaesthetics can induce flushing in some people. That's been reported here.
    Yet there are a number of members here who find they reduce flushing. I am of the opinion that in the long term, they perpetuate it, but that is another matter.

    Ashwagandha helps convert the thyroid hormone T4 into the active T3. Those with low T3, have reduced LPR-1.
    Perhaps those with KP have thyroid dysfunction even at a subclinical level? This is pure speculation of course. I have no knowledge of this.

    http://www.ncbi.nlm.nih.gov/pubmed/23517243

    I shall be following this thread with interest and I wish xxcooperxx success with his experiment. Fingers crossed he has hit on something that can benefit without side effects.
    Last edited by Mistica; 23rd February 2016 at 03:11 AM.
    Previous Numerous IPL.
    Supplements: Niacinamide, Vit K2, low D3, Moderate Dose Vit C, Iodine, Taurine, Magnesium. Very low dose B's. Low dose zinc (to correct deficiency).
    Skin Care: No Cleanser, ZZ cream mixed with Niacinamide gel 4% and LMW HA.

    Treating for gut dysbiosis under specialist care. (This is helping).
    Previous GAPS diet. Testing tolerance of resistant starch.
    Fermented Foods. 2 to 3 days per week, Intermittent fasting -16-18 hours.

  10. #50
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    Quote Originally Posted by Xxcooperxx View Post
    That's fair enough, but she did say she hasn't KPRF which the thread started was the link between KPRF and possibly faulty LPR-1, I hold my hands up and say I don't totally understand it, but ashwagandha apparently can help the LPR-1, that's the reason I'm trying it Dave, and in all honesty today I was quite surprised when I kept checking how my face was when working I wasn't glowing red like usual that's the honest truth...
    Maybe it works also on the sympathetic system. It calms. Most people with the problem KPRF has impaired sympathetic system. It is overactive. Therefore explodes in silly moments "beet" and "fire" face. Because do some people help beta blockers.
    Last edited by poppe; 23rd February 2016 at 12:11 PM.

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