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Thread: KPRF, LRP-1 and Metalloproteinases

  1. #21
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    Quote Originally Posted by realwork View Post
    I don't suppose any of us really know yet, in the very early stages of experimenting its effectiveness. Join us and let us know how you get on!

    I have read that it has to be a root extract. Tablets are just a compressed form of powder anyway, so it won't make much difference.

    realwork

    Hi Realwork

    And what's this supplement suppose do to for KPRF again ? ..

  2. #22
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    However I bought evening primrose oil in the form of "liquid" in the bottle.

    My test supplementation, will be based on:
    - green extract tea (caps)
    - primrose oil (liquid)
    - vitamin C 1000, vitamin D (caps) [maybe summer I can also Vitamin A.)
    - Ashwagandha (caps)

    + maybe also chela minerals.

  3. #23
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    Quote Originally Posted by poppe View Post
    However I bought evening primrose oil in the form of "liquid" in the bottle.

    My test supplementation, will be based on:
    - green extract tea (caps)
    - primrose oil (liquid)
    - vitamin C 1000, vitamin D (caps) [maybe summer I can also Vitamin A.)
    - Ashwagandha (caps)

    + maybe also chela minerals.


    Hi poppe

    Again whats all this meant to do for KPRF ?

  4. #24
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    Quote Originally Posted by davekelly View Post
    [/B]

    Hi poppe

    Again whats all this meant to do for KPRF ?

    Yy... you read first post?

  5. #25
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    Quote Originally Posted by poppe View Post
    Yy... you read first post?
    Yes Mate

    But he needs to explain it all in simple words so people can understand it

    Instead of over complicating things

    Not much to ask is it ?

  6. #26
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    There was someone on the old KPRF forums that claimed Evening Primrose Oil completely cured their condition. Not trying to sound pessimistic but I highly highly doubt that it's anywhere near that effective. It's worth a shot though!


    Wish the old KPRF forums were still active, lots of good info on there.

  7. #27
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    Quote Originally Posted by davekelly View Post
    Hi Realwork

    And what's this supplement suppose do to for KPRF again ? ..
    Quote Originally Posted by ketokprf View Post
    I've noticed that there is not much talk about KPRF around here, and certainly not from a "sciency" perspective, which I guess is really only due to the fact that there is almost no research into KP and related disorders. However, a while ago there was a research paper published which piqued my interest: Whole exome sequencing identifies LRP-1 as a pathogenic gene in autosomal recessive keratosis pilaris atrophicans. The gist of it is that KPAF seems to be linked to a faulty version of the gene LRP-1 (low density lipoprotein related receptor 1), which encodes the LRP-1 receptor, which is abundant in many tissues.

    Before I continue, I must say that I have no hard evidence to suggest that LRP-1 is involved in KPRF. And until there are studies done (if ever), I wont. However, from an empirical view, the pathogenesis of the different KP variants are similiar. Another point to be made, although vauge, is that KP/KPRF/KPAF is reported to somewhat come and go with age (increasing in puberty, slowly improving as one get older).

    Treatment by upregulating LRP-1 (this would be the ideal option imo):

    • Withania Somnifera extract (also known as Ashwangandha). Has been shown to upregulate LRP-1 in mice, with extreme doses, in an alzheimers study. Might be beneficial.
    • Oleocanthal. Found in olive oil, currently no extract available.
    • Resveratrol. (Maybe, not sure).
    In simpler terms, the original poster demonstrates that there is some scientific research indicating a link between keratosis pilaris and a faulty LRP-1 receptor in the body. In other scientific research, Ashwangandha has been shown to improve the LRP-1 receptor.

    realwork

  8. #28
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    Quote Originally Posted by realwork View Post
    In simpler terms, the original poster demonstrates that there is some scientific research indicating a link between keratosis pilaris and a faulty LRP-1 receptor in the body. In other scientific research, Ashwangandha has been shown to improve the LRP-1 receptor.

    realwork
    Thanks Realwork .

    Anyone tried it yet ?

    By the way SRT150 . that person who claimed evening primrose oil cured their KPRF is living in fantasy land . They never showed us any proof with photos .

    I remember reading their story . Words are not proof , we need before and after photos .
    Last edited by davekelly; 19th February 2016 at 11:02 PM.

  9. #29
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    I don't have KPRF, so this thread isn't pertinent to me, however, I am a bad flusher and thought I would just add my experience with Ashwagandha.
    I tested it early last year as it is often recommended for those with hashimoto's, which I have.
    It made me flush like crazy to the point of facial explosion and I only took a low dose for two days. It took me 6 months to recover.
    I also react badly to most anaesthetics/sedatives as they are vasodilating.
    A few others here have reported the same issue.

    Coincidentally, I tried EGCG again yesterday after a negative reaction last year. Today I am redder than I have been in ages. It isn't a transient redder which dissipates after a time. This is here to stay for a long time, which really ticks me off.
    Previous Numerous IPL.
    Supplements: Niacinamide, Vit K2, low D3, Moderate Dose Vit C, Iodine, Taurine, Magnesium. Very low dose B's. Low dose zinc (to correct deficiency).
    Skin Care: No Cleanser, ZZ cream mixed with Niacinamide gel 4% and LMW HA.

    Treating for gut dysbiosis under specialist care. (This is helping).
    Previous GAPS diet. Testing tolerance of resistant starch.
    Fermented Foods. 2 to 3 days per week, Intermittent fasting -16-18 hours.

  10. #30
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    Quote Originally Posted by Mistica View Post
    I don't have KPRF, so this thread isn't pertinent to me, however, I am a bad flusher and thought I would just add my experience with Ashwagandha.
    I tested it early last year as it is often recommended for those with hashimoto's, which I have.
    It made me flush like crazy to the point of facial explosion and I only took a low dose for two days. It took me 6 months to recover.
    I also react badly to most anaesthetics/sedatives as they are vasodilating.
    A few others here have reported the same issue.

    Coincidentally, I tried EGCG again yesterday after a negative reaction last year. Today I am redder than I have been in ages. It isn't a transient redder which dissipates after a time. This is here to stay for a long time, which really ticks me off.
    Hi Mistica, Does drinking green tea give you a bad reaction, too?

    I brew it and let ot cool, but it seems to make me flushed or red.

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