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Thread: Rosmarinic acid, Gallic acid, and Caffeic acid study on type-1 Rosacea

  1. #1
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    Default Rosmarinic acid, Gallic acid, and Caffeic acid study on type-1 Rosacea

    Very interesting and found to have a real therapeutic effect. In some subjects it reduced erythema, in others it held it at baseline. With placebo the rosacea progressed in some patients, it didn't in others. These three molecules combat inflammation (cytokine release), mast cell release and angiogenesis - basically all the things that we'd need to control to reduce / arrest redness.

    Combination of new multifunctional molecules for erythematotelangiectatic rosacea disorder

    Methods

    Dermocosmetic active ingredient is composed of three glucosylated derivatives of natural plants hydroxybenzoic acid and hydroxycinnamic acids (rosmarinic acid, gallic acid, and caffeic acid). Anti-inflammatory, anti-angiogenesis, and anti-degranulation studies were done on cellular models (keratinocytes, mast cells, and endothelial cells). Efficiency of the active ingredient in comparison to placebo was assessed clinically on human volunteers having erythematotelangiectatic rosacea. The active and placebo were applied topically twice a day for 28 days. Biometrical analyses were done using a siascope tool.

    Results

    We found that the active ingredient decreases inflammation (inhibition of interleukin-8 and tumor necrosis factor release), decreases degranulation of mast cells (inhibition of histamine release), and controls angiogenesis mechanism (inhibition of the production of vascular endothelial growth factor and neovessel formation) on cellular models. Study on human volunteers confirmed macroscopically the efficiency of this active ingredient, as we observed no neovessel formation and less visible vessels.

    Conclusion

    Although rosacea is a skin condition disorder that is difficult to heal, the studies have shown that this active ingredient could be a dermocosmetic support, especially for erythematotelangiectatic rosacea armamentarium. The active ingredient was topically applied on the face for 28 days and improved erythematotelangiectatic rosacea symptoms either by decreasing them (vessels are less visible) or by limiting their development (any neovessels). The active ingredient decreases inflammation (inhibition of interleukin-8 and tumor necrosis factor release), decreases degranulation of mast cells (inhibition of histamine release), and limits the angiogenesis process (inhibition of vascular endothelial growth factor production and neovessel formation).
    Well worth a read!

  2. #2
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    We were talking about this in another thread. I would not be waiting for the commercial product but would start adding some natural sources of these acids to my diet and topical routine.

    http://www.rosaceagroup.org/The_Rosa...stuff&p=315566

  3. #3
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    I'm using it...and it seems to be working for my fixed red nose. Taken it down by about 20%, and have had hardly any pustules, or exacerbations - people with rosacea noses need to get on this! It's found in Apaisac Biorga Anti Rouger

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    That seems great. So you are using Apaisac Biorga Anti Rouger with good results? I will give it try. Do you know if they ship to Denmark?

  5. #5
    Senior Member Brady Barrows's Avatar
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    Thanks for the link to the article which I have posted here.
    Brady Barrows
    Join the RRDi

  6. #6
    Member RAWARALBIHN's Avatar
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    Is there any natural alternative to this cream with RGC substances?

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