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Thread: Did people recover from Mirvaso long term rebound flushing & pain

  1. #1
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    Default Did people recover from Mirvaso long term rebound flushing & pain

    I recently developed very mild, light flushing as an adverse reaction to antibiotics that I was prescribed, but didn't need. I went to see a dermatologist a few months after the initial antibiotic trigger. She prescribed brimonidine Mirvaso (called Onreltea in Canada). She did not tell me any side effects or adverse effects. In my search for onreltea I did not find anything. It wasn't until I had adverse effects that I found others posting about mirvaso. I used Mirvaso 3 times spaced a week apart. Ever since I started using it I have been living in a nightmare of constant pain and flushing for 7 weeks. When my flushing episode ends I return to my normal pale skin with no redness. But, the intense pain never stops, it gets worse, but never goes away. It's been 4 weeks since I last used it. I have had to go on an extremely restrictive diet in order to attempt to avoid food triggers. I am losing too much weight, I only weigh 96 pounds now. I can only eat at home because I can't eat at restaurants. I have chronic, extreme pain in my nose, and nerve pain through my jaw, and sensitive painful eyes. Sometimes the pain gets so bad that I can't even walk or think. I have had to take a break from working and I am mostly home bound at this point which is very depressing. I just want to get back to the way I was before I ever used mirvaso. I want the flushing to tone down and stop. I want the constant pain in my nose and jaw to stop, I want my eyes to stop hurting. Is there any hope that I will still be able to recover from this. It has been 4 weeks. I can't imagine living my life this way. My life as I knew it is ruined at this time. My life now revolves around this chronic condition that has been brought on by mirvaso. I'm a mother as well, and my job is/was as a dance teacher and performer. I just need to know if people recovered from the long term rebound flushing (and pain).

  2. #2
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    Default Just want to add that

    The doctors do not believe me so far.

  3. #3
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    Default Numbness also

    I have numb tingly lips and jaw and nose. I'm obviously afraid to take more meds. Not sure if there is any way to recover from this. I hope it's temporary. I'm trying to be upbeat and happy and not stressed. I wish I had known. I wish the doctor had warned me.

  4. #4
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    Hello,

    Dont loosing hope, you will found a solution

    I remember that i felt rebounds effects of mirvaso still 1mounth to 2mounth after the last apply.
    I felt some wierd felling sensations at the face. (i really dont know how to explain that)
    like my skin was burning inside but cold at the surface. swetting more, feeling like sweating (but it wasnt)
    I didnt had pain like you explain but iam pretty sure that each person should feeling and experiment some subjective pain.

    I really hope that this will go.
    I think that now you have a little anxiety, you really need to take good sleeping, work to your breathe. Dont panic (maybe take some propanolol b-blocker)

  5. #5
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    Dont apply anything to your skin during 1mounth also.

    And in one mounth, hydratation cream and sunscreen

  6. #6
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    Default Thank you!

    Quote Originally Posted by kalis View Post
    Dont apply anything to your skin during 1mounth also.

    And in one mounth, hydratation cream and sunscreen
    Thank you so much for your messages. Did you get better after two months. I hope I get better. Thanks for your advice and support. Also thank you to people that sent me messages. I am new here and still not completely sure how to use this and how to reply to messages. I'm so sad and so upset that I used this. I had no idea. I was ok. And now feel my life has been ruined and it's going to impact my children's lives. I will try to not give up hope.

  7. #7
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    I agree that one of the hardest things is that we 'had no idea'. I also was given no warning of possible severe side effects, so when I first got rebound flushing I didn't recognise it for what it was, so ignored it. In fact I had been told that the longer I used the cream, the more permanent would be the blood vessel constriction, which is a complete falsehood. The total opposite is true, sadly.

    We must help get this dangerous stuff banned.

    Please make sure you write to Galderma to complain, and also to the pharmaceutical licencing authorities.

  8. #8
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    Default I'm so sorry!

    Quote Originally Posted by EllyS View Post
    I agree that one of the hardest things is that we 'had no idea'. I also was given no warning of possible severe side effects, so when I first got rebound flushing I didn't recognise it for what it was, so ignored it. In fact I had been told that the longer I used the cream, the more permanent would be the blood vessel constriction, which is a complete falsehood. The total opposite is true, sadly.

    We must help get this dangerous stuff banned.

    Please make sure you write to Galderma to complain, and also to the pharmaceutical licencing authorities.
    Yes, your experience is exactly like mine. I didn't fully understand why suddenly my condition had escalated so much. I was even misdiagnosed with an auto-immune disease. So, I tried it again. I thought that using it would make my condition better in the long term. But, instead it has given me a much worse condition to try and live with. It has ruined my life as I knew it. I now have to build a different life of simply learning how to cope with what this topical med has done to me. I hope we can recover. I wish I had gone to a naturopath and never gone to a dermatologist. Like you said, we had no idea. But, now I can't get any doctors to help me. I'm dealing with this all on my own. Trying to deal with it. I'm making doctor appointments weekly. My life revolves around dealing with this condition and trying to have enough strength in my weakened state to go to doctor appointments trying to get a referral to a neurologist. Once I get a referral it will be a six month wait, but I can't even get a referral. I have severe trigeminal nerve pain. They don't believe me. Thank you for replying.

  9. #9
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    Default Yeah

    Quote Originally Posted by kalis View Post
    Hello,

    Dont loosing hope, you will found a solution

    I remember that i felt rebounds effects of mirvaso still 1mounth to 2mounth after the last apply.
    I felt some wierd felling sensations at the face. (i really dont know how to explain that)
    like my skin was burning inside but cold at the surface. swetting more, feeling like sweating (but it wasnt)
    I didnt had pain like you explain but iam pretty sure that each person should feeling and experiment some subjective pain.

    I really hope that this will go.
    I think that now you have a little anxiety, you really need to take good sleeping, work to your breathe. Dont panic (maybe take some propanolol b-blocker)
    The inside of my nose feels all painfully infiltrated with menthol and black pepper. It hurts to breath through my nose. I have numbness in my lips and gums. Feels all swollen in my nose. Very hard to breath. My doctor said that my nostrils are extremely narrow to begin with. The doctors have put me through hell.

  10. #10
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    Default How long did you use it?

    Quote Originally Posted by EllyS View Post
    I agree that one of the hardest things is that we 'had no idea'. I also was given no warning of possible severe side effects, so when I first got rebound flushing I didn't recognise it for what it was, so ignored it. In fact I had been told that the longer I used the cream, the more permanent would be the blood vessel constriction, which is a complete falsehood. The total opposite is true, sadly.

    We must help get this dangerous stuff banned.

    Please make sure you write to Galderma to complain, and also to the pharmaceutical licencing authorities.
    How long did you use it? how many times did you use it? I used it 3 times, but once a week, so I used it for 2 weeks. It's been 4 weeks since I stopped, so that's 6 weeks with symptoms, but 4 weeks in recovery. The first time I used it, my nose went pale for 48 hours. Edit to add: I see that you used it for one week.
    Last edited by TinyDancer; 27th September 2015 at 04:05 PM.

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