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Thread: An Oral Phosphodiesterase Inhibitor (Apremilast) for Inflammatory Rosacea in Adults:

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    Default An Oral Phosphodiesterase Inhibitor (Apremilast) for Inflammatory Rosacea in Adults:

    Rosacea is a chronic skin disorder characterized by facial flushing, persistent erythema, telangiectasias, and inflammatory papules and pustules. In addition to the physical manifestations, rosacea may contribute to lower self-esteem, thereby having significant psychosocial implications.1 Some patients do not respond to conventional treatments for rosacea or are unable to tolerate the adverse effects; therefore, effective new therapies are needed. We sought to investigate the safety and efficacy of apremilast, an oral phosphodiesterase 4 inhibitor, for the treatment of moderate to severe inflammatory rosacea. Apremilast modulates multiple proinflammatory and anti-inflammatory pathways through targeted phosphodiesterase type 4 inhibition, including augmenting interleukin 10 production, which in turn suppresses other proinflammatory cytokines.2,3 Inhibitors of phosphodiesterase type 4 have been tested for treatment of many inflammatory dermatologic diseases4 but never for rosacea.
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