Results 1 to 2 of 2

Thread: Superiority of ivermectin 1% cream over metronidazole 0.75% cream

  1. #1
    Senior Member
    Join Date
    Mar 2014
    Location
    Paris
    Posts
    180
    Country: France

    Post Superiority of ivermectin 1% cream over metronidazole 0.75% cream

    Superiority of ivermectin 1% cream over metronidazole 0.75% cream in treating inflammatory lesions of rosacea: a randomized, investigator-blinded trial.
    Taieb A1, Ortonne JP, Ruzicka T, Roszkiewicz J, Berth-Jones J, Peirone MH, Jacovella J; The ivermectin Phase III study group.
    Author information
    Abstract
    BACKGROUND:

    Few therapeutic alternatives currently exist in the treatment of papulopustular rosacea (PPR).
    OBJECTIVES:

    Demonstrate superiority of once-daily ivermectin 1% cream (IVM 1%) vs. twice-daily metronidazole 0.75% cream regarding percent reduction of inflammatory lesions in subjects with moderate to severe PPR.
    METHODS:

    In this Phase 3, investigator-blinded, randomized, parallel group study, subjects received IVM 1% once daily, or metronidazole 0.75% twice daily over 16 weeks. Efficacy assessments were inflammatory lesion counts and Investigator's Global Assessment (IGA). Safety assessments included incidence of adverse events (AEs) and local tolerance parameters. Subjects evaluated their disease following a 5-grade scale and completed questionnaires.
    RESULTS:

    A total of 962 subjects were randomized to receive IVM 1% (n=478) or metronidazole 0.75% (n=484). At week 16, IVM 1% was significantly superior to metronidazole 0.75% in terms of reduction from baseline in inflammatory lesions (83.0% vs. 73.7%; p<.001), observed as early as week 3 (last observation carried forward - LOCF). IGA results (subjects "clear" or "almost clear") also favoured IVM 1%: 84.9% vs. 75.4%, respectively (p<.001). Incidence of AEs was comparable between groups and local tolerability was better for IVM 1%. More subjects receiving ivermectin rated their global improvement as "excellent" or "good."
    CONCLUSIONS:

    Ivermectin 1% cream was significantly superior to metronidazole 0.75% cream and achieved high patient satisfaction. This article is protected by copyright. All rights reserved.

    This article is protected by copyright. All rights reserved.
    KEYWORDS:

    ivermectin; metronidazole; papulopustular rosacea; patient satisfaction; quality of life; randomized clinical trial

    http://www.ncbi.nlm.nih.gov/pubmed/25228137

  2. #2
    Senior Member
    Join Date
    Mar 2014
    Location
    Paris
    Posts
    180
    Country: France

    Default

    Sorry I just discover a thread now : http://www.rosaceagroup.org/The_Rosa...053#post302053

Similar Threads

  1. Ivermectin cream
    By moomy in forum News, research articles and current affairs
    Replies: 3
    Last Post: 17th June 2014, 08:00 AM
  2. Permethrin cream or ivermectin oral??
    By LornaS in forum Topical and oral products (non-prescription)
    Replies: 2
    Last Post: 7th October 2011, 08:41 PM
  3. Ivermectin and face cream
    By Ghost in forum Topical and oral products (non-prescription)
    Replies: 2
    Last Post: 15th June 2011, 04:06 AM
  4. metronidazole eyelash cream?
    By sunbad in forum Similar and co-existing conditions
    Replies: 0
    Last Post: 22nd May 2006, 02:37 AM
  5. Metronidazole .75 + Ovace Cream
    By Jake in forum Prescription medications
    Replies: 0
    Last Post: 22nd October 2005, 02:26 PM

Tags for this Thread

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •