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Thread: Candida Biofilms are stopped with Farnesol

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    Senior Member Tom Busby's Avatar
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    Default Candida Biofilms are stopped with Farnesol

    Here’s an interesting article, “Farnesol-mediated inhibition of Candida albicans yeast growth,” found at: onlinelibrary.wiley.com/doi/10.1002/yea.1501/pdf

    This article reports that farnesol stops candida biofilms by preventing the yeast form from switching to the hyphal form. I think the hyphal form is probably a necessary stage in the formation of a biofilm.

    My best guess is that farnesol will break down any yeast biofilm because malassezia and candida appear to be similar in this respect.

    Farnesol is a natural oily alcohol found in essential oils and plant species such as lily, jasmine, rose, chamomile, green tea and many more.

    Farnesol is apparently very effective in very low concentrations, probably about 0.02%, and the retail cost for 5 grams of 95% farnesol is $48 including shipping. I ordered some today from a chem lab supply store.

    If you read the article, keep in mind that μM means a micromole, an SI unit equal to 10^−6 mole. For example, 1 mole (6.02x10^23) of water molecules, with a molecular weight of 18 grams per mole, weighs 18 grams and occupies 18 ml of volume. So when the article discusses 100 μM of farnesol, assuming farnesol has a molecular weight similar to water, the article is using about 0.018 grams of farnesol.

    If any of my math is incorrect, or if I misunderstood the article, I would greatly appreciate being corrected by people with a chemistry background.

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    Senior Member Tom Busby's Avatar
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    All right, now I'm certain I need some help with my math, because I just learned that water has a molecular weight of 18 grams per Mole, but farsenol has a molecular weight of 222.37 grams per Mole.

    So should I multiply my estimates (above) by a factor of about twelve? Because 222 is 12 times greater than 18? And so, I should not have written 0.03%, but instead I should have written 0.36% farsenol?

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    Hey Tom, I'm no chemist and not good at the math stuff. I have been reading about biofilms for that last two days and experimented with some home mixes. I knew something about xylitol used in the holistic dental because I have listen to a podcasts on natural/holistic healing for a few years. I noticed that Xylitol kept appearing l in some medical research papers & sites. Since my doctor told me to use this for my coffee sweetener I had some at home. Yesterday I started experimenting with the xylitol. I mixed with water, creams, lotions and applied to my face and let stay on for a while then face followed by washing with either pine tar soap or another yeast killing topical. It really works! Then I read up on which essential oils that may naturally have Farnesol. I have a good collection essential oils but the only one I had at home on the listed was Jasmine. I incorporated some of that oil in a lotion cream and used it after applying the xylitol water. I'm not sure if adding the Jasmine essential oil helped because the results from xylitol are so extreme. I just hope it does not stop working as many other topicals in the past, but maybe it was due to the protective biofilm.

    If this continues to work on the biofilm protecting the yeast in something similar to layers (not getting to scientific) it may be possible to remove this in a much shorter time period than the months expected.

    I'm really excited about this but want to give warning to others. This is not something for beginners. It would be best that you try some of weaker yeast treatments/topicals before trying these products. This is not dangerous and I'm not trying to be bossy, but unless you have read and know the basics on yeast/fungus/mycosis it may freak someone out. The results that I got today may send some running to the ER because I have never seen anything comparable other than 2nd/3rd degree burn that is healing/peeling. I knew it was not really my skin but the biofilm.


    There are a few sites with similar comments about these two ingredients. Here is the link and a snip of the paper where I got the basic info and idea to experiment.

    http://www.skintherapyletter.com/2012/17.7/1.html


    "Atopic dermatitis (AD) affects 10-20% of children with 60% of cases occurring within a child's first year and 85% before the age of 5.23 Although spontaneous resolution is seen in a majority of patients by 18 years of age, many cases persist into adulthood as evidenced by the 1-3% prevalence of AD among the adult population.24 It is well known that AD patients are colonized with S. aureus and this organism has been shown to exist in both dry skin as well as areas of severe dermatitis.25 Disease severity has been directly correlated to the degree of S. aureus colonization and therapy generally fails to improve symptoms in the presence of high S. aureus counts.26 CLSM has demonstrated the presence of biofilms on mouse skin inoculated with AD S. aureus isolates,27 as well as in skin stripping and biopsy specimens from 11 AD patients.9

    The difficulty in eradicating S. aureus colonization with conventional antibiotic therapy may be due to the presence of biofilms. It is hypothesized that normal skin microflora, such as Staphylococcus epidermidis (S. epidermidis), has an important role in suppressing the growth of S. aureus by metabolizing sebum and, thus, creating a low pH environment that is inhibitory to pathogenic organisms.28 Since S. aureus and S. epidermidis exhibit similar antibiotic susceptibility, a logical rationale for therapy may be to specifically target S. aureus biofilm. A recent in vitro study29 examined the effects of farnesol and xylitol on S. aureus biofilms and showed that each agent alone inhibited a different stage of biofilm formation and, when used concomitantly, they inhibited biofilm formation and also disrupted mature biofilm. The MIC of farnesol was lower for S. aureus than S. epidermidis, indicating the potential of this agent to selectively target the pathogenic organism. In a clinical study of 17 patients with AD,28 a 0.02% farnesol and 5% xylitol (FX) combination emollient cream significantly decreased the number of S. aureus organisms, as well as the ratio of S. aureus to total aerobic skin microflora with an observed increase in coagulase-negative staphylococci. S. aureus biofilm, demonstrated in the intercellular spaces of the stratum corneum prior to therapy, was completely absent after 7 days of FX topical application. No adverse effects of FX were noted after 4 weeks of therapy. Ideal topical agents for the treatment of AD should selectively reduce pathogenic biofilm and restore the balance of skin microflora without the irritant effects typically seen with current topical germicides.29 "
    Last edited by Samilynn; 25th July 2013 at 03:51 AM.

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    Quote Originally Posted by Samilynn View Post
    There are a few sites with similar comments about these two ingredients. Here is the link and a snip of the paper where I got the basic info and idea to experiment.

    http://www.skintherapyletter.com/2012/17.7/1.html
    Research into bioflims is so exciting. Thanks Tom and Samilynn for your information. I particularly like the conclusion of the above report:

    "... In the field of dermatology, biofilms appear to be taking center stage, and their presence likely explains the chronic nature of many cutaneous disorders. It is expected that further knowledge regarding the molecular mechanisms that govern biofilm formation, their virulence, and drug resistance will vastly improve the limited therapeutic options currently available to today's clinician."

    Yaaay!!!

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    Senior Member Mistica's Avatar
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    All this is bringing back memories of a David Flemming and his topical fluconazole/DMSO experiment.

    Actually, I have been thinking about this independently of this thread due to my and my doctor's suspicion that I have a fungal component to my disease.

    I can't help with the math either, but that aside, have you ever considered tinkering with DMSO, Tom?

    You might find the following interesting. Another rosacean adventurer. Ok, he wasn't treating a fungal infection, but you might find some of the ingredients he used, interesting. Particularly the green tea, thymol.
    DMSO has benefits other than being a great penetrator and carrier.

    http://www.neopax.com/Artemis/rosacea/

    Sorry about the derailing of topic, although it is still related.
    Previous Numerous IPL.
    Supplements: Niacinamide, Vit K2, low D3, Moderate Dose Vit C, Iodine, Taurine, Magnesium. Very low dose B's. Low dose zinc (to correct deficiency). Tocotrienols.
    Skin Care: No Cleanser, ZZ cream mixed with Niacinamide gel 4%.

    Treating for gut dysbiosis under specialist care. (This is helping).
    Previous GAPS diet. Testing tolerance of resistant starch.
    Fermented Foods. Daily Intermittent fasting -16-18 hours.

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    In ref. to DMSO. I have been tinkering with it for aprox. 3 years, after my breast cancer ordeal I was interested in alternative/holistic healing. This was way before my skin issues this year. Even my new doctor Trowbridge said he cannot legally endorse DMSO and actually has a clinic hand out paper with his observations & precautions. Since I brought up the subject of DMSO he show some positive excitement about DMSO's healing capabilities. He said let me be perfectly clear I cannot prescribe nor persuade the use of DMSO because of the state medial board. His hand out gives some cautions but does give links to DMSO sites and the work of Stanley Jacob MD. DMSO is mentioned in Trobridges book The yeast syndrome which was co-authored by Morton Walker, who also wrote the book DMSO Natures Healer.

    I read up on DMSO extensively and and know how to use and store it safely. I have the 99.99% pure gel and the liquid. I started the use of DMSO with my dog's skin issues a few years ago. She had some completely bald hair less spots and with the application of DMSO I could see new hair growing in that spot within 2 days. It can be a great healing product if used properly but it also can do some damage if you are not educated on the subject. I have mixed a very small amount with many of my topical included the 2 % Nizoral shampoo but use it sparingly. The only negative thing I can say is if you use it topically on a large area on take it internally is the bad sulpher, rotten egg stinky smell. My family complains about this smell and iit may take a day or more to go away. That is one of the main reasons I don't use it much or is because you stink so bad due the to chemical process mix with our individual bodies.

    I will be interested in your link provided.

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    Senior Member Tom Busby's Avatar
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    Farnesol and xylitol are also reviewed here, in the first four pages: http://synapse.koreamed.org/Synapse/Data/PDFData/0166AAIR/aair-2-235.pdf .

    Apparently farnesol and xylitol are also used to treat dry skin rashes, which I think are usually called atopic dermatitis. Is this true?

    David Fleming's work is very well done, and his write up is great too. Thanks for the link!

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    Quote Originally Posted by Tom Busby View Post
    Farnesol and xylitol are also reviewed here, in the first four pages: http://synapse.koreamed.org/Synapse/...aair-2-235.pdf .

    Apparently farnesol and xylitol are also used to treat dry skin rashes, which I think are usually called atopic dermatitis. Is this true?

    David Fleming's work is very well done, and his write up is great too. Thanks for the link!
    Link not working even with a copy paste.

    As far as the atopic dermatitis in my opinion - I think most doc's just do the Eeny, meeny, miny, moe to name most skin rashes. I requested several look at mine with magnification and/or do a scrape biopsy and all refused. They all insisted on their medical diagnosis from just a quick glance. I now have about 6 different scientific medical names for this mess on my face and body. Also 1 MD and 1 dermatologist thought they should dable in the psychiatric field and make a diagnosis. Because I seem obsessed with my face issues and then I tried to explain and showed them the yeast hypea spores that had landed on my reading glasses. Who would not be obsessed with something like this just showing up one day and no past history of skin issues. They have no idea what it's like to be suddenly disfigured and that it changes the way you look and the way you live every day.

    OK, rant over.

    *edit to add - now the links working. Thanks.

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    Tim and Samilyyn, thanks for sharing your research again, this sounds really encouraging. Someday in the not too distant future, a generation will be born that does not have to suffer from skin disease. As someone who has suffered with eczema all my life, that notion really makes me smile.

    I have been making my own mix of roughly equal parts Nizoral, ACV, Cetaphill and (melted) petroleum jelly which I apply to my face twice a day. Good results so far, it keeps my skin soft, moist and relatively flake free... I have a massive build up of biofilm on my chin and around the base of my neck and collar bone area though. It appears to be very entrenched and it's going to take a long time to shift it... I expect to add Xylitol and some essential oil (containing Farnesol) to my arsenal this weekend and will report back.

    Tom, do you have any idea which essential oil has the highest concentration of Farnesol?

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    Quote Originally Posted by Davo View Post
    Tom, do you have any idea which essential oil has the highest concentration of Farnesol?
    In February 2008 I posted that someone wrote to the UK Times newspaper saying they'd attained good results from applying sandalwood oil and a thread began on this subject.

    I found this 'essential' oil to be very potent. It needed to be mixed with a carrier oil but for the sake of getting rid of biofilms I think it might work very well as I understand Australian sandalwood contains high amounts of Farnesol.

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