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Thread: More news about Brimonidine

  1. #181
    Senior Member Mistica's Avatar
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    LuluDog,

    If you are already experiencing rebound flushing, it is not going well.
    There is no point in my saying anything further about what will probably happen to you, as you can read all about it in this thread.

    For everyone else, my hell continues. I further diluted the brim by two more drops during the last week. So that now makes it 1 in 17. The severe flushing continues. Now and then I manage to get through one night of sleep without my face exploding, but the norm is pacing about most of the night beating back a flushing, swollen face.
    I sit here now, after such a night. I spent from 1am to 3am beating it back. Then I tried sitting up in bed, but fell asleep as I was exhausted and awoke so bad I could have cried. It is hell. Lord knows how much angiogenesis has taken place.
    Previous Numerous IPL.
    Supplements: Niacinamide, Vit K2, low D3, Vit A. Moderate Dose Vit C, Iodine, Taurine, Magnesium. Very low dose B's. Low dose zinc (to correct deficiency).
    Skin Care: No Cleanser, ZZ cream mixed with Niacinamide gel 4% and LMW HA 2%, ethyl ascorbate 2%.

    Treating for gut dysbiosis.(This is helping).
    Previous GAPS diet. Have now introduced lots of fibre.
    Fermented Foods. Intermittent fasting -16-18 hours.
    Oral Colostrum. Helps reduce food reactions.

  2. #182
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    Mistica, I'm so sorry this is happening to you. You must be frantic with pain and worry. It's so unfair after the hell you've been through. Do you dare use the occasional (and very rare) low dose over-the-counter hydrocortisone to calm your skin as you stop the Brimonidine? Thinking of you and hoping you move towards healing.
    • 58 yr old woman
    • Rosacea at 48, debilitating at 52
    • Clonidine 100mgc ev. 8 hrs;
    • Remeron 15mg nightly;
    • Zebeta=Bisoprolol=Beta blocker 5mg nightly;
    • Brimonidine worked well initially, then MASSIVE rebound flushing and damage;
    • Countless IPL with Lumenis One;
    • Now purpuric V Beam with Candela Perfecta; more clearance, less downtime than IPL;
    • Botox (with mesotherapy needles), good not great results;
    • Monthly Kenalog injection to blunt debilitating flushing.

  3. #183
    Senior Member Mistica's Avatar
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    Quote Originally Posted by WrinkledClue View Post
    Mistica, I'm so sorry this is happening to you. You must be frantic with pain and worry. It's so unfair after the hell you've been through. Do you dare use the occasional (and very rare) low dose over-the-counter hydrocortisone to calm your skin as you stop the Brimonidine? Thinking of you and hoping you move towards healing.
    I am too scared to try anything else. In the past I have had adverse reactions to hydrocortisone anyway and being a cream that would just add to my list of problems.
    The area above my upper lip is terrible now. I am even thinking of having that one area treated with IPL. Yes, a risk, but it is SO BAD and I can't even open my mouth to talk or eat without it engorging with blood. That area has been treated the least with IPL, so in theory it is possible it would not only survive treatment, it might benefit. Yet, due to other damage elsewhere, I feel apprehensive about having any more IPL at all.
    There is no v-beam in my area and anyway I would be far too scared to try that.

    I know I have started the CAP with the hope it will wipe out the beast, but the brimonidine hell is due to a different cause. It has to be stopped. Also, as I can't take doxy, and so far, can't find anything to replace it with, I am having doubts that I can even do the CAP.
    When my doctor returns from holiday in early Dec, he will have to contact Dr Stratton for advice about alternative antibiotics. And, I have to hope Dr Stratton will bother to reply. Meanwhile I keep deteriorating.
    Previous Numerous IPL.
    Supplements: Niacinamide, Vit K2, low D3, Vit A. Moderate Dose Vit C, Iodine, Taurine, Magnesium. Very low dose B's. Low dose zinc (to correct deficiency).
    Skin Care: No Cleanser, ZZ cream mixed with Niacinamide gel 4% and LMW HA 2%, ethyl ascorbate 2%.

    Treating for gut dysbiosis.(This is helping).
    Previous GAPS diet. Have now introduced lots of fibre.
    Fermented Foods. Intermittent fasting -16-18 hours.
    Oral Colostrum. Helps reduce food reactions.

  4. #184
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    Default Brimonidine

    WrinkledClue-

    I'm curious as to how your recent experience has been with Brimonidine? As I've read through this thread it seems like it was working very well for you. Are you still using Brimonidine on a regular basis? Any issues with rebound redness?

    My GP gave me a prescription, but I've been hesitant to try it out of fear of causing a bigger issue than I have now.

  5. #185
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    as a side issue: does anyone else here feel like it would be good if our esteemed moderators would rename this thread?
    calling it "more good news" when experimenting with Brimonidine has been extremely bad for some people
    seems potentially very misleading to anyone who doesn't read the entire thread - and that may be a lot of people.

  6. #186
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    Well, it's taken four months, but now I too am getting rebound flushing from the Brimonidine.

    Maybe it took so long because I was using such a tiny amount?

    Brimonidine's great when it's working, but when it wears off, I'm redder than I was before putting it on. Which is awful.

    I'm so disappointed. I was heartbroken when so many others had bad results with it, and now I'm having bad results with it too.

    Such a shame. More hope, dashed.
    • 58 yr old woman
    • Rosacea at 48, debilitating at 52
    • Clonidine 100mgc ev. 8 hrs;
    • Remeron 15mg nightly;
    • Zebeta=Bisoprolol=Beta blocker 5mg nightly;
    • Brimonidine worked well initially, then MASSIVE rebound flushing and damage;
    • Countless IPL with Lumenis One;
    • Now purpuric V Beam with Candela Perfecta; more clearance, less downtime than IPL;
    • Botox (with mesotherapy needles), good not great results;
    • Monthly Kenalog injection to blunt debilitating flushing.

  7. #187
    Senior Member Mistica's Avatar
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    Quote Originally Posted by WrinkledClue View Post
    Well, it's taken four months, but now I too am getting rebound flushing from the Brimonidine.

    Maybe it took so long because I was using such a tiny amount?

    Brimonidine's great when it's working, but when it wears off, I'm redder than I was before putting it on. Which is awful.

    I'm so disappointed. I was heartbroken when so many others had bad results with it, and now I'm having bad results with it too.

    Such a shame. More hope, dashed.
    I am sorry to hear that.

    Unfortunately, I can't say I am surprised.
    You take clonidine as well, so perhaps this has delayed your facial reaction to brimonidine. Clonidine acts on the same receptor.

    During the last few days, I have further diluted the brim. Down to 1 in 21 drops (water). Also, a few days ago I added a fan to my bedroom. At first, I found it a huge help and I actually got several hours sleep. My nose flushed a bit, but a few applications of an icepack and it seemed to settle. I fell back asleep. My cheeks were pretty good in the morning.
    Then the fan malfunctioned and we had to get a new one. This is more powerful and I feel it has aggravated my face. Plus I might be now reacting to the reduced brim dosage. Not sure. Anyway, I am a wreck today. Usually I recover to a managable state after being up and about for a period of time. Not today. It is terrible.

    Having said all that, what is your plan? To try and wean yourself off the drug, or quit cold turkey?

    I have discovered there is such a thing called adrenergic urticaria. ( I am currently being screened for various types by the immunologist). It doesn't look anything like our flushing, BUT, seeing brimonidine works on the same receptor, I wonder what hell we have caused with the mast cells?
    I did mention my brim use to the specialist, but he was reticent and I took this as a lack of interest. I have to email him with some information shortly, so I am going to mention it to him again, asking for feedback.
    Previous Numerous IPL.
    Supplements: Niacinamide, Vit K2, low D3, Vit A. Moderate Dose Vit C, Iodine, Taurine, Magnesium. Very low dose B's. Low dose zinc (to correct deficiency).
    Skin Care: No Cleanser, ZZ cream mixed with Niacinamide gel 4% and LMW HA 2%, ethyl ascorbate 2%.

    Treating for gut dysbiosis.(This is helping).
    Previous GAPS diet. Have now introduced lots of fibre.
    Fermented Foods. Intermittent fasting -16-18 hours.
    Oral Colostrum. Helps reduce food reactions.

  8. #188
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    Hello Mistica,

    I quit the Brimonidine cold turkey.

    I used low dose hydrocortisone over-the-counter for two days to deal with the rebound flushing.

    Then I quit that, too. Now I'm all recovered from my Brimonidine experiment.

    Amazingly, I'm getting better, too-- maybe the result of all the heavy V Beams I've had in the last year.

    Hoping for better health for all of us.
    • 58 yr old woman
    • Rosacea at 48, debilitating at 52
    • Clonidine 100mgc ev. 8 hrs;
    • Remeron 15mg nightly;
    • Zebeta=Bisoprolol=Beta blocker 5mg nightly;
    • Brimonidine worked well initially, then MASSIVE rebound flushing and damage;
    • Countless IPL with Lumenis One;
    • Now purpuric V Beam with Candela Perfecta; more clearance, less downtime than IPL;
    • Botox (with mesotherapy needles), good not great results;
    • Monthly Kenalog injection to blunt debilitating flushing.

  9. #189
    Senior Member Mistica's Avatar
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    Nov 2007
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    Goodness, you are lucky.

    I react to hydrocortisone too Perhaps the cream is part of the problem too. I cant tolerate any creams. This is hell
    Previous Numerous IPL.
    Supplements: Niacinamide, Vit K2, low D3, Vit A. Moderate Dose Vit C, Iodine, Taurine, Magnesium. Very low dose B's. Low dose zinc (to correct deficiency).
    Skin Care: No Cleanser, ZZ cream mixed with Niacinamide gel 4% and LMW HA 2%, ethyl ascorbate 2%.

    Treating for gut dysbiosis.(This is helping).
    Previous GAPS diet. Have now introduced lots of fibre.
    Fermented Foods. Intermittent fasting -16-18 hours.
    Oral Colostrum. Helps reduce food reactions.

  10. #190
    Senior Member Mistica's Avatar
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    Nov 2007
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    Well this just keeps getting better and better!

    I have spent the last two nights in the ER with severe flushing, beet red cheeks end of nose and other areas, swelling, including aread above upper lip, even upper lip, inside mouthc as well, internally somehow to my inner ear. I had to use so much ice to reduce the swelling and of course, even with ice gel packs covered, I now had sore, freezer burn skin.
    Due to nobody really understanding what had happened to me and them thinking it was an allergy, I was there for hours. By the time they got the point, the decision was made to give me oral prednisone. ( Which I feel nervous about. Just one dose 50 mg)

    To cut a long story short, I am now SO, SO SEVERE with permanent redness/beetness, visible redness and easily engorged skin, not to mention the pain, I will have to have IPL again, or laser. There is no other way. No amount of antibitiocs in the world is going to reverse this mess.

    Two years ago, I was housebound with a similar case, and I went through hell. To have climbed out of that and now having returned to it, due to a stupid mistake to use a drug advised by a doctor who is affiliated with the company and who obviously wasn't giving accurate reports on other rosaceans, makes me feel sick to the pit of my stomach.
    I have lost everything. And more. I will no doubt receive more structural damage from IPL, but to remain in this state is unacceptable.

    http://www.rosaceagroup.org/The_Rosa...ral-prednisone
    Previous Numerous IPL.
    Supplements: Niacinamide, Vit K2, low D3, Vit A. Moderate Dose Vit C, Iodine, Taurine, Magnesium. Very low dose B's. Low dose zinc (to correct deficiency).
    Skin Care: No Cleanser, ZZ cream mixed with Niacinamide gel 4% and LMW HA 2%, ethyl ascorbate 2%.

    Treating for gut dysbiosis.(This is helping).
    Previous GAPS diet. Have now introduced lots of fibre.
    Fermented Foods. Intermittent fasting -16-18 hours.
    Oral Colostrum. Helps reduce food reactions.

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