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Thread: I can't find the study on 660nm leds and decrease in melanin production (frustrated)

  1. #1
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    Default I can't find the study on 660nm leds and decrease in melanin production (frustrated)

    Hi guys, I've been loking for the study or post I read last year on this site about the effects of 660nm leds on melanocytes (decrease in melanin production). I think this was the subject. I've been searching for it in the LLLT sub-forum the whole morning without any luck. Anyone has the link?

    Many thanks,
    Abraham

  2. #2
    Moderator phlika29's Avatar
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    I did a forum search and didnt come up with anything so I did a search on google

    Could it have been this (but it talks about blue light?)

    or this mentions something:
    http://www.trueadvance.com/files/documents/REDLED.pdf

  3. #3
    Moderator phlika29's Avatar
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    I think I found it! but not from this forum
    http://www.smartskincare.com/forum/v...ic.php?p=13869

    The significant decrease of melanin levels after red LED
    irradiation has been already observed in our previous clinical
    study on acne treatment [48]. In addition, many subjects
    spontaneously reported their perception of
    brightening of the skin tone in the present study, as had
    been also the case in the previous study. We performed
    Schmorl’s staining to elucidate any changes in the amount
    of melanin pigment between before and after treatment,
    but could not find any significant difference. We hypothesize
    that the decrease in the melanin levels measured by
    Mexameter were possibly as the result of reasons other
    than the direct decrease in the amount of melanin pigment,
    for example, changes in the reflection of light from the epidermis
    or alteration in the absorption and scattering characteristics
    of light in the dermis.

  4. #4
    Senior Member Mistica's Avatar
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    Just for your interest.

    I have had about nine red light therapy sessions in a doctor's clinic.
    I was initially worried it would worsen my melasma. It hasn't, which is a relief, however, it hasn't lightened it either.
    Previous Numerous IPL.
    Supplements: Niacinamide, Vit K2, low D3, Moderate Dose Vit C, Iodine, Taurine, Magnesium. Very low dose B's. Low dose zinc (to correct deficiency).
    Skin Care: No Cleanser, ZZ cream mixed with Niacinamide gel 4% and LMW HA.

    Treating for gut dysbiosis under specialist care. (This is helping).
    Previous GAPS diet. Testing tolerance of resistant starch.
    Fermented Foods. 2 to 3 days per week, Intermittent fasting -16-18 hours.

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    Thanks phlika29, you're great

    Very good find, this wasn't what I read but it's even better

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    Given your current interest in this area, you might find this interesting (if not old news):


    Preclinical Report
    LED photoprevention: Reduced MED response following multiple LED exposures

    Background and ObjectivesAs photoprotection with traditional sunscreen presents some limitations, the use of non-traditional treatments to increase skin resistance to ultraviolet (UV) induced damage would prove particularly appealing. The purpose of this pilot study was to test the potential of non-thermal pulsed light-emitting diode (LED) treatments (660 nm) prior to UV exposure in the induction of a state of cellular resistance against UV-induced erythema.
    Study Design/Materials and MethodsThirteen healthy subjects and two patients with polymorphous light eruption (PLE) were exposed to 5, 6, or 10 LED treatments (660 nm) on an EXPERIMENTAL anterior thigh region. Individual baseline minimal erythema doses (MED) were then determined. UV radiation was thereafter performed on the LED EXPERIMENTAL and CONTROL anterior thigh areas. Finally, 24 hours post-UV irradiation, LED pre-treated MED responses were compared to the non-treated sites.
    ResultsReduction of erythema was considered significant when erythema was reduced by >50% on the LED-treated side as opposed to CONTROL side. A significant LED treatment reduction in UV-B induced erythema reaction was observed in at least one occasion in 85% of subjects, including patients suffering from PLE. Moreover, there was evidence of a dose-related pattern in results. Finally, a sun protection factor SPF-15-like effect and a reduction in post-inflammatory hyperpigmentation were observed on the LED pre-treated side.
    ConclusionsResults suggest that LED based therapy prior to UV exposure provided significant protection against UV-B induced erythema. The induction of cellular resistance to UV insults may possibly be explained by the induction of a state a natural resistance to the skin via specific cell signaling pathways and without the drawbacks and limitations of traditional sunscreens. These results represent an encouraging step towards expanding the potential applications of LED therapy and could be useful in the treatment of patients with anomalous reactions to sunlight. Lesers Surg. Med. 40:106-112, 2008. © 2008 Wiley-Liss, Inc.

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