Rosacea News May 2007

1. RRF funded study: cathelicidins and VEGF reduced by IPL/PDL

The NRS has published on their blog some results from a recently
concluded study. The study was titled `Structural and biologic changes
in the rosacea skin induced by pulse dye laser and intense pulsed
light', and was part funded by the now defunct Rosacea Research

2. wearing contact lenses and ocular rosacea

Many rosacea sufferers, especially those who suffer from ocular rosacea
wonder if they will ever be able to regularly and comfortably wear
contact lenses. When your eyes are sore, gritty and blurry would one
want to consider trying to apply a contact lens ? I don't have any
ocular symptoms but I do know that I take it as right to be able to
wear contacts instead of the hassle of glasses.

PAPER: In this article, Contact Lens Wear in The Rosacea Patient (which
was mentioned in a recent edition of Rosacea Review), Dr. Mannis lists
the factors involved with the successful wearing of contact lenses when
you suffer from ocular symptoms.

3. melanotan: could it cause skin cancer ?

This article from the DailyMail is offering some warnings about being
too quick to jump on the Melanotan II bandwagon. It is worth
remembering on top of all of the warnings below, that Melanotan
specifically as a rosacea treatment is also something we know very
little about. I think that the combination of rosacea sufferers
desperate for relief, the relative ease of obtaining Melanotan, and the
fact that so little is known about its effects, is a recipe for
dangerous outcomes.

NEWS PAPER: Pretty pills: The dark side of the latest underground
beauty trend

4. elidel vs. protopic, does it work for rosacea bumps ?

This recently published blind study suggests that elidel (pimecrolimus)
is no better for rosacea papules and pustules than the vehicle it uses.

A previous study in 2005, Pimecrolimus for treatment of acne rosacea
suggested that elidel could indeed be useful for rosacea, but this
study was not a double blind study - it was not compared to another
inactive topical.

PAPER: Pimecrolimus cream 1% for papulopustular rosacea: a randomized
vehicle-controlled double-blind trial.

5. incyclinide dosage trials: 40mg too much

Collagenex has announced that their ongoing trials to find the best
dosage for Incyclinide have discovered that 40mg can cause

PRESS RELEASE: CollaGenex Pharmaceuticals Discontinues 40 mg Cohort of
Phase II Dose-Finding Study of Incyclinide for the Treatment of Acne