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Thread: Singulair is amazing..

  1. #151
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    why would these antihistamines help rosacea?

  2. #152
    Senior Member nat007's Avatar
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    Quote Originally Posted by rednessator View Post
    why would these antihistamines help rosacea?
    Because they block histamine release and histamine is a blood vessel dilator. Antihistamines won't help everyone with rosacea, but if someone flushes from foods high in histamine for instance (think old cheeses, fish, vanilla etc) or has underlying allergies and triggers from them, then antihistamines can make the skin less red and less flushed.
    Uses: 22,5 mg mirtazapine, clonidine and propranolol, Xyzal at times.
    Diet: trying low sugar, no gluten and dairy, high protein diet.
    Link to my rosacea blog:http://scarletnat.blogspot.com

  3. #153
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    Quote Originally Posted by ginaisred View Post
    Hey, I Just checked as I was confused if Montelukast and Singulair are the same. Montelukast is the main ingredient in singulair, but I am just taking Montelukast, so we shall see if that helps as I know some people have had mixed responses with Singulair....

    I haven't tried planquenil, I am very nervous about trialling malarial drugs, because of the side effects - yellow skin and eye problems?. I already think my meds may have caused some hair loss, although prof chu said it is down to my low iron levels and stress, which is probably true.....

    Are you on plaquenil?
    Hey Gina -

    Wondering how you were getting on with the Montelukast? Hope it is helping

    I am ~10 weeks into plaquenil (something like that) and no change as of yet. *Perhaps* some less swelling ... but hard to say since nasalcrom for me already helps some with the swelling. (My swelling is nose/sinus areas.) No bad side effects though so I will keep going for a couple of months, why not.

    Best,

    Lizzy

    PS Not sure if you tried gabapentin? I know some ppl (including me) do not react well to gabapentin but I believe that one is worth trying ... helps sometimes with menopausal hot flashes. Lyrica is fine for me, I take it as needed for flushing pain.
    Last edited by laser_cat; 4th October 2017 at 08:15 PM.

  4. #154
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    I know earlier on in this thread there was discussion of the use of H1 and H2 anti-histamines. I wondered if anyone in the UK uses both - if so do you need a prescription for your H2 anti-histamines? Which H1 and which H2 anti-histamines do you use? Thanks.

    Currently I just use Benadryl once a day.

  5. #155
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    Quote Originally Posted by laser_cat View Post
    Hey Gina -

    Wondering how you were getting on with the Montelukast? Hope it is helping

    I am ~10 weeks into plaquenil (something like that) and no change as of yet. *Perhaps* some less swelling ... but hard to say since nasalcrom for me already helps some with the swelling. (My swelling is nose/sinus areas.) No bad side effects though so I will keep going for a couple of months, why not.

    Best,

    Lizzy

    PS Not sure if you tried gabapentin? I know some ppl (including me) do not react well to gabapentin but I believe that one is worth trying ... helps sometimes with menopausal hot flashes. Lyrica is fine for me, I take it as needed for flushing pain.
    Hi lizzy, so lovely to hear from you. I think 10weeks on plaquenil is quite a short period of time; I think it takes much longer to start working, than other pills. I don't know though, as I haven't tried them.

    I don't think the montelukast is working for me, I don't know if it has had a benefit or not. My flushing is pretty bad at the moment, I keep waking up bright red and flushed, and my anxiety / embarrassment flushing is horrendous. I cannot stop going bright red. I wasn't sure if the montelukast helped or made it worse, since sometimes I had better skin and sometimes worse. I wasn't sure if montelukast was the cause or if it is just rosacea being unpredictable. It also made me super sleepy and I kept waking up at 10am and feeling so tired all day. I will stop it for a week or two and try it again but I just don't know if it helps.......

    I hate my rosacea at the moment. Flush Flush Flush. Add in Hairloss. I am pretty down at the moment.

    I haven't tried gabapentin, but since I have low low oestrogen maybe it would help. I am only 25 and my estrogen is in the WORRINGLY low stage. Hopefully when I gain weight, it may help. Trying to put on more weight at the moment.

    Keep me updated. So glad you aren't getting any nasty side effects X

  6. #156
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    I have also tried montelukast (Singulaire) and found it somewhat helpful for rosacea but with side effects (in particular anxiety and digestion issues).

    I am interested if anyone has found good versions of H2 anti-histamines available over the counter in pharmacies in the UK?

  7. #157
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    Quote Originally Posted by ginaisred View Post
    Hi lizzy, so lovely to hear from you. I think 10weeks on plaquenil is quite a short period of time; I think it takes much longer to start working, than other pills. I don't know though, as I haven't tried them.

    I don't think the montelukast is working for me, I don't know if it has had a benefit or not. My flushing is pretty bad at the moment, I keep waking up bright red and flushed, and my anxiety / embarrassment flushing is horrendous. I cannot stop going bright red. I wasn't sure if the montelukast helped or made it worse, since sometimes I had better skin and sometimes worse. I wasn't sure if montelukast was the cause or if it is just rosacea being unpredictable. It also made me super sleepy and I kept waking up at 10am and feeling so tired all day. I will stop it for a week or two and try it again but I just don't know if it helps.......

    I hate my rosacea at the moment. Flush Flush Flush. Add in Hairloss. I am pretty down at the moment.

    I haven't tried gabapentin, but since I have low low oestrogen maybe it would help. I am only 25 and my estrogen is in the WORRINGLY low stage. Hopefully when I gain weight, it may help. Trying to put on more weight at the moment.

    Keep me updated. So glad you aren't getting any nasty side effects X


    i feel so bad that singulair has not brought the expected relief to you.

    just wonder what kind of constant redness and flushing feelings do you have?
    ——— (1) “simple hot/burning flushing or redness”, i.e. kind of like being very close in front of bonfire for a long time, then face turns very hot / burning and red, and may or may not co-exist with the weird distending feeling (this feeling is kind of like a cake gets baked in oven and after a while the cake becomes more swollen and expanding; here the cake is the face, and swelling/expanding feeling can be self feeling or can be both self feeling and visually noticeable.)
    or (2) “inflammation burning flushing or redness”, i.e. besides everything from (1), your face feels like getting hot spicy red pepper rubbed into your skin on and off or all the time, or feels like salt on open wound, or feels like mild or moderate acid burning / inflammation kind burning...


    Singulair (montelukast) is antagonist to leukotriene b4, which may work in a feedback loop with ll-37, which is thought to be the culprit in the never-ending inflammation expression in rosacea. however, we all know that there are so many different kind of causes and “mechanisms / pathways” which lead to our different type 1 rosacea and that is why different people respond very differently to treatments. so the possible explanation here may be: if your type 1 rosacea is not ll-37 related, then montelukast may not help at all.


    above is just my little shallow understanding. if anyone thinks differently or can provide more insight, please share your thoughts and help all of us learn more.
    Last edited by ephemerality; 25th November 2017 at 10:41 PM.

  8. #158
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    Quote Originally Posted by ephemerality View Post
    i feel so bad that singulair has not brought the expected relief to you.

    just wonder what kind of constant redness and flushing feelings do you have?
    ——— (1) “simple hot/burning flushing or redness”, i.e. kind of like being very close in front of bonfire for a long time, then face turns very hot / burning and red, and may or may not co-exist with the weird distending feeling (this feeling is kind of like a cake gets baked in oven and after a while the cake becomes more swollen and expanding; here the cake is the face, and swelling/expanding feeling can be self feeling or can be both self feeling and visually noticeable.)
    or (2) “inflammation burning flushing or redness”, i.e. besides everything from (1), your face feels like getting hot spicy red pepper rubbed into your skin on and off or all the time, or feels like mild or moderate acid burning / inflammation kind burning...


    Singulair (montelukast) is antagonist to leukotriene b4, which may work in a feedback loop with ll-37, which is thought to be the culprit in the never-ending inflammation expression in rosacea. however, we all know that there are so many different kind of causes and “mechanisms / pathways” which lead to our different type 1 rosacea and that is why different people respond very differently to treatments. so the possible explanation here may be: if your type 1 rosacea is not ll-37 related, then montelukast may not help at all.


    above is just my little shallow understanding. if anyone thinks differently or can provide more insight, please share your thoughts and help all of us learn more.
    Hey, how interesting. Maybe that's why I don't see any difference. I've tried montelukast again and still don't know if things have improved or not. I am still flushing so I guess not.

    Regarding what flushing I have, I would say I have a mix of flushing. I get burning red flushing which is so uncomfortable and feels so hot and just not nice. This happens during embarrassment, getting upset (emotions basically) and worry and also hot environments. I also have red cheeks when I wake up in the morning but not necessarily painful flushing, just red. This condition is such a pain.

  9. #159
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    Quote Originally Posted by ginaisred View Post
    Hey, how interesting. Maybe that's why I don't see any difference. I've tried montelukast again and still don't know if things have improved or not. I am still flushing so I guess not.

    Regarding what flushing I have, I would say I have a mix of flushing. I get burning red flushing which is so uncomfortable and feels so hot and just not nice. This happens during embarrassment, getting upset (emotions basically) and worry and also hot environments. I also have red cheeks when I wake up in the morning but not necessarily painful flushing, just red. This condition is such a pain.
    sounds like yours is less ll-37 related but more direct disfunction of mechanism of either neuro or capillaries or both... maybe you can ask prof tony chu more about those when u see him in dec?

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    Quote Originally Posted by blusher View Post
    This may sound weird, but I have been on and off Atkins over the past 5 years. I know, I know...Atkins diet is unhealthy and bad for you! Anyway...Every time I am on the Atkins diet, within 3 weeks of starting it, my face improves dramatically. I don't know why this is?? The diet for me is hard to follow, that is why I can't stay on it, but the benefits to my skin are incredible. I was even able to go off of metrogel completely. When I stop the diet, it all comes back within a week or so. I told my doc, and he though maybe it was a change of eating (obviously)...no sugar, white flower etc... everything I crave. It isn't the increase of water consumption, because I always drink at least 8-8oz glasses of water daily. Has anyone else had this experience? Now I am on Slimfast, and my face is the wost it has ever been. Maybe too much sugar?
    listen to your body. if its helping your onto something. however atkins is not realistic , you are right. have you tried card cycling? I dont know why carbs would do it but then again our bodies are still a mystery. breif explenation carb cycling:
    I dont know what your goals are or weight is like so im just throwing this out there but carb cycling when i would body build would be like this:
    M 200g carbs
    T 150 g
    W 100
    Th 50
    F 0 exceot trace amnts
    S you could see if you can maintain 0
    Sun you can carb load which would be 300-400.
    it keeps your body guessing. i was also 240lbs +.

    if your 100lbs you can start way lower. it can be a 3 cycle all the way to a 7 day...

    just a thought.

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