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  1. Replies
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    A very encouragin study PART 2

    Rapamycin (RPM) is a specific inhibitor of mammalian target of rapamycin (mTOR) and has a long history ofhuman use as an immunosuppressive agent. Recent investigations have explored the use of RPM as...
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    A very encouraging study Part 1

    The most encouraging study I've read. Had to edit it due to limited space. email me and I will send a PDF copy of the study (with pictures).
    Perry
    p.s. Prometheus...if you're out there, please...
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    Sticky: Hello, I think a (major) flaw in the "bacterial...

    Hello,
    I think a (major) flaw in the "bacterial overgrowth" theory is that PO antibiotics were among the first tx modalities targeting rosacea (this is bc initially rosacea was considered a variant...
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    Well now, don't I just feel like the horses ass...

    Well now, don't I just feel like the horses ass (actually, I've felt like the ass for my last 3-4 posts on this thread, but sometimes once a hole is dug...kind of hard to climb out, you know)....
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    Appreciate your opinion. I agree it's time to...

    Appreciate your opinion.
    I agree it's time to end the argument.
    Perry
    p.s. I will certainly inform you if ever a "problem" and I need your assistance -- you can count on it.
  7. Replies
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    O.k., short and sweet: Clinical decisons and...

    O.k., short and sweet:
    Clinical decisons and guidelines are based on in vivo (look it up) data and studies (e.g. clinical trials), NOT experimental data (e.g. dead mouse skin). So, in a nutshell,...
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    Well, it's just that I firmly believe that a...

    Well, it's just that I firmly believe that a kids' acting "gangsta" is not good either for his long-term economic prosperity and success. Not trying to be hard, but he might as well get a clue early...
  9. Replies
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    Ok...I was a dick so I'm going to try to be a...

    Ok...I was a dick so I'm going to try to be a little more professional. I briefed over the article (I'll post if if you like) and the gel did show the percent you stated...but in vitro mouse skin. So...
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    Well...I don't know about "ignorant"...maybe rude...

    Well...I don't know about "ignorant"...maybe rude and obnoxious....I'll look at the study later (btw...a study is "experimental" data...not "clinical" data...(clinical data is what is observed in the...
  11. Sticky: Re: Jordan's mom to all who want to read experience with Dr

    Gotta admit...the constant fixation on GN has raised some eyebrows.... :shock:
    Roscoe (Perry's dad...I think)
  12. Hi, TIA is the acryonym for "transient ischemic...

    Hi,
    TIA is the acryonym for "transient ischemic attack" -- a ministroke (usually caused by a temp. lack of oxygen to the brain due to an occlusion such as a cerebral vasospasm or embolus that clogs...
  13. Caran, You're welcome (dang...I must have had a...

    Caran,
    You're welcome (dang...I must have had a TIA during the last part of my last post here...).
    Perry
  14. Hi Caran, I used Alphagan(R) eye drops. It's my...

    Hi Caran,
    I used Alphagan(R) eye drops. It's my understanding that these drops were the active ingredient used in this SansRosa experiments (I mixed the drops with various moisturizers simply for...
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    I was really hoping for an reply concerning the...

    I was really hoping for an reply concerning the "600 percent better absorption and greater clinical efficacy....Hmmm....I guess the good doctor wasn't a "lazy dumbass" after all....
    Perry
    p.s. It...
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    Hi TP, It was my best attempt at ridicule...

    Hi TP,
    It was my best attempt at ridicule regarding the mindset that rationalizes talking like an ignorant monkey in order to appear "wit it". I guess I must be losing my touch.
    Perry
  17. Tompkin, Thats a very relevant question -- one I...

    Tompkin,
    Thats a very relevant question -- one I can't answer. It works both ways...mix with the wrong excipient, and the absorption could be inhibited (exipient attaches on the molecule and keeps...
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    Yo...word....yeah...I agreez...yall quit hatin on...

    Yo...word....yeah...I agreez...yall quit hatin on da homie
    GN...yall juz still trippin cuz he suckered yall wit da r-r-r-roscea and yall still cant deal wit it...so pimp dat!
    tomaoro then,
    Perry...
  19. Hi Phlika, Hope all is well with you. The...

    Hi Phlika,
    Hope all is well with you.
    The intricacys(sp?) of topical drug delivery are pretty complicated (to me, anyway), but some of the principles aren't too myserious. Hydrated skin absorbs...
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    Hi, JtothaK, where did the info. about the "600...

    Hi,
    JtothaK, where did the info. about the "600 percent better absorption and greater efficacy" come from? No trying to argue, but this is interesting to me (if one is 600 times more potent than the...
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    HI, Propranolol or any beta blocker. It works...

    HI,
    Propranolol or any beta blocker.
    It works differently than clonidine, has a better side effects profile, does not product reflex hypertension if skipped doses, improves mortality in patients,...
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    Hello, To those with strong feelings about...

    Hello,
    To those with strong feelings about steroids consider this:
    One of the most horrid aspects of rosacea is its unpredictability. It also generally gets worse with time. So, for example, that...
  23. Hi, I had posted some info. ealier concering the...

    Hi,
    I had posted some info. ealier concering the obstacles in topical compounding -- upon review sounded kind of preachy, so here is a shorter bit of info concerning topicals:
    The goal is to get...
  24. Hi, Decongestant. Oxymetazoline and other...

    Hi,
    Decongestant. Oxymetazoline and other constrictors work by binding the alpha 1 receptors on the capillaries, constricting the vasculature. This thus decreases the swelling in the nasal cavity,...
  25. Hi, In contrast to the rebound nasal congestion...

    Hi,
    In contrast to the rebound nasal congestion typically encounted after long-term use of nasal decongestants, I'm not aware of rebound redness, itching or conjunctivitis being commonly associated...
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