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NIH - Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by

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  • NIH - Amelioration of Compound 48/80-Mediated Itch and LL-37-Induced Inflammation by

    Numerous inflammatory skin disorders display a high prevalence of itch. The Mas-related G protein coupled receptor X2 (MRGPRX2) has been shown to modulate itch by inducing non-IgE-mediated mast cell degranulation and the release of endogenous inducers of pruritus. Various substances collectively known as basic secretagogues, which include inflammatory peptides and certain drugs, can trigger MRGPRX2 and thereby induce pseudo-allergic reactions characterized by histamine and protease release as...

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