Thalidomide ameliorates rosacea-like skin inflammation and suppresses NF-κB activatio

[Dan3dwards]

Found this interesting article online not sure if it is old news at all?



Thalidomide alleviates LL37-induced rosacea-like skin inflammation.


Thalidomide reduces the production of chemokines and cytokines associated with rosacea.


Thalidomide represses LL37-induced Th1/Th17 immune responses in the skin.


Thalidomide decreases cutaneous angiogenesis in LL37-induced rosacea-like mice.


Thalidomide suppresses NF-κB activation in keratinocytes.

https://www.sciencedirect.com/science/article/pii/S0753332219318955

[Dutch1]

Very interesting, thanks for sharing.

[antwantsclear]

Very interesting, thanks for sharing.

Thalidomide is more commonly used as a last resort for pain medication for severe mouth ulcers. Several pain medications are more commonly used for rosacea with some success such as gabapentin - there is quite a lot of evidence in the literature that this can help rosacea, which will help encourage doctors to prescribe it. I suspect, given the risks and concerns around thalidomide, it would be quite difficult to convince many doctors to prescribe it for rosacea - at least in the UK.

Here is an earlier letter on a same topic, though not sure if anyone can find a full text link for it:

https://www.ncbi.nlm.nih.gov/pubmed/25753523