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Mas-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs

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  • Mas-related G protein-coupled receptors X (MRGPRX): Orphan GPCRs with potential as targets for future drugs

    Mas-related G protein-coupled receptors (GPCRs) of subfamily X, designated MRGPRX, are primate-specific orphan receptors that belong to the δ-branch of rhodopsin-like, class A GPCRs. Four distinct subtypes exist, MRGPRX1, -2, -3, and -4, MRGPRX2 having the lowest degree of similarity with the others. Due to their expression on sensory neurons and immune cells, and their roles in pain perception and transmission, itch, inflammation, immune defense, pseudo-allergic reactions, wound healing, and...

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