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The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases

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  • The immunosuppressive activity of artemisinin-type drugs towards inflammatory and autoimmune diseases

    The sesquiterpene lactone artemisinin from Artemisia annua L. is well established for malaria therapy, but its bioactivity spectrum is much broader. In this review, we give a comprehensive and timely overview of the literature regarding the immunosuppressive activity of artemisinin-type compounds toward inflammatory and autoimmune diseases. Numerous receptor-coupled signaling pathways are inhibited by artemisinins, including the receptors for interleukin-1 (IL-1), tumor necrosis factor-α...

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