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Alarmins/stressorins and immune dysregulation in intractable skin disorders

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  • Alarmins/stressorins and immune dysregulation in intractable skin disorders

    Unlike other barrier epithelia of internal organs, the stratified squamous epithelium of the skin is always exposed to the external environment. However, the robust barrier structure and function of the skin are highly resistant against external insults so as to not easily allow foreign invasions. Upon sensing danger signals, the innate immunity system is promptly activated. This process is mediated by alarmins, which are released passively from damaged cells. Nuclear alarmins or stressorins are...

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