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Study: Topical 3% Tranexamic Acid

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  • Study: Topical 3% Tranexamic Acid

    What are the chances of finding a topical ingredient that repairs skin permeability defect, inhibits vascular growth factor and inhibits inflammatory cytokines. According to this Chinese Study such a topical already exists. Here's what happened when they used it on 30 Rosacea patients:http://www.sciencedirect.com/science...27811715000506

  • #2
    Originally posted by Rory View Post
    What are the chances of finding a topical ingredient that repairs skin permeability defect, inhibits vascular growth factor and inhibits inflammatory cytokines. According to this Chinese Study such a topical already exists. Here's what happened when they used it on 30 Rosacea patients:http://www.sciencedirect.com/science...27811715000506
    Welcoming research. But that definition " improved rosacea" somewhat sounds familiar?
    I googled and found quite a few topicals with tranexamic acid available. One of them Skinapeel Tranexamic Acid Skin Whitening Serum 10ml.
    Anyone tried that?

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    • #3
      This study is old news but how quickly we can forget. The skin barrier is being talked about more and more on this forum and science is finding it to be relevant in many skin disorders. Some people are anxiously awaiting new topicals which are still going through clinical trials. We always believe what's next to come must be better than what's already here. There are many topicals available with Tranexamic Acid. So why wait years for something new.

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      • #4
        Originally posted by Rory View Post
        This study is old news but how quickly we can forget. The skin barrier is being talked about more and more on this forum and science is finding it to be relevant in many skin disorders. Some people are anxiously awaiting new topicals which are still going through clinical trials. We always believe what's next to come must be better than what's already here. There are many topicals available with Tranexamic Acid. So why wait years for something new.
        Is it not genetically that we are predefined with "good or bad" skin barrier?
        Is it possible to change one's skin barrier with a topical?

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        • #5
          Well certainly it would appear people with Atopic Dermatitis have a genetic fault which leads to a permanently impaired skin barrier. I don't think it can be corrected but there are some new topicals on the way which have had great results in clinical trials. A Recent study on twins has shown that Rosacea is possibly connected to genetics, but it has never been suggested that Rosacea is caused by an impaired skin barrier. It is most likely a secondary event induced by Demodicosis and/or inflammation. Studies have shown that Rosacea skin has high Trans Epidermal Water Loss and lacks hydration. A non irritating,non occlusive skin barrier topical should help, but on it's own it doesn't address any of the primary causes. Target the primary cause and the skin barrier should return to normal.

          Seb Derm is a different kettle of fish. Skin barrier seems to have a more primary role than previously thought. I hope that some of these new Topicals like Dermadexin live up to their expectations. Restoring the skin barrier and inhibiting inflammation without suppressing the skins immunity is the key to treating SD. We'll just have to wait and see if any of these new topicals have really found this key.

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