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Remission of rosacea induced by reduction of gut transit time

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  • Remission of rosacea induced by reduction of gut transit time

    Rosacea is a chronic disorder characterized by hypersensitivity of the facial vascu-lature, presenting with intense flushing eventually leading to chronic erythema andtelangiectasia. Although the precise aetiology of rosacea is not known, numerousassociations with inflammatory gastrointestinal tract disorders have been reported.Furthermore, substance P-immunoreactive neurones occur in considerably greaternumbers in tissue surrounding affected blood vessels suggesting involvement ofneurogenic inflammation and moreover plasma kallikrein–kinin activation isconsistently found in patients. In this report, a patient without digestive tract diseaseis described, who experienced complete remission of rosacea symptoms followingingestion of a material intended to sweep through the digestive tract and reduce transittime below 30 h. It is possible that intestinal bacteria are capable of plasma kallikrein–kinin activation and that flushing symptoms and the development of othercharacteristic features of rosacea result from frequent episodes of neurogenicinflammation caused by bradykinin-induced hypersensitization of facial afferentneurones. The possible relevance of this hypothesis to other conditions featuringafferent hypersensitivity, such as fibromyalgia, is considered.
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  • #2
    I wanted to create a thread on this study, but it already exists.

    Who has already tried to reduce transit time?

    Comment


    • #3
      Originally posted by Ryohiku View Post
      I wanted to create a thread on this study, but it already exists.

      Who has already tried to reduce transit time?
      It might be worth looking into taking a prokinetic to reduce gut transit time. Prucalopride at 0.5mg a day four hours after eating and just before bed, is a standard treatment for SIBO.

      Comment


      • #4
        Originally posted by Dan3dwards View Post
        It might be worth looking into taking a prokinetic to reduce gut transit time. Prucalopride at 0.5mg a day four hours after eating and just before bed, is a standard treatment for SIBO.

        where did you see that Prucalopride is a treatment for sibo?

        Comment


        • #5
          Originally posted by Ryohiku View Post
          where did you see that Prucalopride is a treatment for sibo?
          A lengthy article but worth a read

          https://medium.com/@stkirsch/insight...bo-c091bb5aa00

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          • #6
            Thanks.

            So did you try Prucalopride ? Have you some others advices ?

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            • #7
              Originally posted by Ryohiku View Post
              Thanks.

              So did you try Prucalopride ? Have you some others advices ?
              I am a complicated case as I will always have some form of SIBO due to me having surgery to remove my ileocecal valve (Due to crohns disease). The ileocecal stops bacteria from moving from the large intestine to the small intestine, so without it there will always be the potential for bacteria to migrate to and from the large intestine. I have just started prucalopride although I had to obtain it through unusual channels (Basically my ex-wife is obtaining this for me from India) too early to say if it is working at the moment. I also have the added complication of severe facial psoriasis as I literally have psoriasis growing on top of my rhinophyma and pustules. The four derms I have seen say they have never quite seen a case like mine as you either have one or the other diseases not both on top of each other. I would advise getting a breath test to make sure you have SIBO, I have had 5 breath tests and each time I have had high hydrogen levels. Hope this advice helps.

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              • #8
                Originally posted by Dan3dwards View Post
                I am a complicated case as I will always have some form of SIBO due to me having surgery to remove my ileocecal valve (Due to crohns disease). The ileocecal stops bacteria from moving from the large intestine to the small intestine, so without it there will always be the potential for bacteria to migrate to and from the large intestine. I have just started prucalopride although I had to obtain it through unusual channels (Basically my ex-wife is obtaining this for me from India) too early to say if it is working at the moment. I also have the added complication of severe facial psoriasis as I literally have psoriasis growing on top of my rhinophyma and pustules. The four derms I have seen say they have never quite seen a case like mine as you either have one or the other diseases not both on top of each other. I would advise getting a breath test to make sure you have SIBO, I have had 5 breath tests and each time I have had high hydrogen levels. Hope this advice helps.
                Do you think SIBO can contribute to subtype 1 rosacea? I tested positive for high hydrogen levels but assumed that SIBO was more linked to subtype 2? What are your thoughts?

                Comment


                • #9
                  Originally posted by Seb91 View Post
                  Do you think SIBO can contribute to subtype 1 rosacea? I tested positive for high hydrogen levels but assumed that SIBO was more linked to subtype 2? What are your thoughts?
                  I think subtype is a false approach to rosacea. For me, there is:

                  1. Rosacea caused by demodex mites
                  2. Rosacea caused by the gut

                  We can have either one or the other, or both. And so the patients develop different symptoms and the doctors categorize them into subtypes.

                  But the question you should ask yourself is: do I have digestive problems? Flush after meals? Bloating? Other symptoms like fatigue, hormonal problems, bad sleep?

                  If so, there is a good chance that you have SIBO and not only demodex mites

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                  • #10
                    Originally posted by Seb91 View Post
                    Do you think SIBO can contribute to subtype 1 rosacea? I tested positive for high hydrogen levels but assumed that SIBO was more linked to subtype 2? What are your thoughts?
                    Hi Seb

                    How are you treating your SIBO?

                    Did you ever take Rifraxam?

                    If so, was there any flushing from die off?

                    Many thanks,
                    Bluedog

                    Comment


                    • #11
                      Originally posted by Ryohiku View Post
                      I think subtype is a false approach to rosacea. For me, there is:

                      1. Rosacea caused by demodex mites
                      2. Rosacea caused by the gut

                      We can have either one or the other, or both. And so the patients develop different symptoms and the doctors categorize them into subtypes.

                      But the question you should ask yourself is: do I have digestive problems? Flush after meals? Bloating? Other symptoms like fatigue, hormonal problems, bad sleep?

                      If so, there is a good chance that you have SIBO and not only demodex mites
                      I have SIBO, I tested positive last month. However, I don’t have any stomach symptoms, just rosacea which consists of constant warmth on face, with mild redness and severe burning and hypersensitivity. Will treat SIBO to see whether my skin improves.



                      Sent from my iPhone using Tapatalk

                      Comment


                      • #12
                        Originally posted by Ryohiku View Post
                        I think subtype is a false approach to rosacea. For me, there is:

                        1. Rosacea caused by demodex mites
                        2. Rosacea caused by the gut

                        We can have either one or the other, or both.
                        Ryohiku, have you solved your rosacea then? If you're able to localize it to these issues, there are already known solutions which should work. I'm skeptical those are the only causes.

                        I have subtype 1 (persistent redness + flushing) and I'm not convinced either of those are issues for me.

                        Comment


                        • #13
                          Originally posted by beherenow View Post
                          Ryohiku, have you solved your rosacea then? If you're able to localize it to these issues, there are already known solutions which should work. I'm skeptical those are the only causes.
                          I have subtype 1 (persistent redness + flushing) and I'm not convinced either of those are issues for me.
                          Just curious, what do you think subtype 1 is? Have you learned that subtypes are an old school approach to rosacea and the phenotype classification improved the diagnosis of rosacea?
                          Brady Barrows
                          Blog - Join the RRDi


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                          • #14
                            Originally posted by Seb91 View Post
                            Do you think SIBO can contribute to subtype 1 rosacea? I tested positive for high hydrogen levels but assumed that SIBO was more linked to subtype 2? What are your thoughts?
                            I will be honest I haven’t a clue how SIBO is involved in rosacea, although interestingly a lot of medical literature is pointing to systemic inflammation along the IL 17 pathway for rosacea and perhaps this is where SIBO might be contributing to rosacea. I’m seeing SIBO more as a potential trigger than a cause of rosacea, as a lot of people have sibo and don’t have rosacea. So perhaps our skin is genetically programmed to react in that way. I will say a GI doc I spoke to said that lactolose breath tests give a lot of false positives for SIBO, hence why I was also tested with a Glucose test which is more accurate.

                            I think it is not a bad idea to try a pro-kinetic if you do suspect SIBO. Also it’s worth following dr mark Pimentel on Twitter and Facebook as he is really advancing the science in the area of SIBO, apparently they have isolated the bacteria that causes SIBO and are working on new treatments etc.

                            Comment


                            • #15
                              I linked this on another thread but again gut inflammation is implicated again in this recent study, its not terribly new news, but it in my case it is interesting that people with Crohn’s disease have a higher incidence of SIBO.

                              https://journals.lww.com/md-journal/...y_bowel.1.aspx

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