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  • Originally posted by Brady Barrows View Post
    In searching for Mirvaso YouTube videos found this one, entitled 'Galderma'

    LOL, this is how Galderma's own think about such video presentations
    http://www.cafepharma.com/boards/sho...d.php?t=545725


    "The National Meeting Video. What is that gonna look like? Any thoughts?"

    "Hmmm good call. I think David Wilk comes on stage with a line like "Where'd everybody go" The lights dim. Fade to video. I picture some type of man made tough mudded obstacle course where various home office personnel hop out of the mud in slow mo and runs to the finish line which is shaped like a Galderma G. After high fiving each other several dozen times they turn to the camera, flex their biceps, and in unison shout, "Galderma, Only the Strong Survive"

    "I think this year's video is all in the editing. They will have a clip of FH pumping up the crowd, then cut to a Traverse getting towed. Have Dr. B talking about the psychosocial impact of Rosacea, then cut to a screaming rebound patient. A scene from camp wonder, then a scene of a former IC winner on the unemployment line. Whatever it looks like I can assure you three things - a massive production budget, bad acting, and a video that goes right to the trash. But people will applaud out of fear."

    "Too predictable. We are going for gold etc! You're not a bronze or silver medal rep, no, you are golden! Quick show some motivational clip from unexpected athletes winning gold. An underhanded insult. Have a former Olympic gold medal skier give a speech on a recorded video. So touching "team Galderma!"
    All a fraud..."
    My rosacea related blog: http://scarletnat.blogspot.com/2012/...edication.html

    Comment


    • Originally posted by nat007 View Post
      LOL, this is how Galderma's own think about such video presentations
      http://www.cafepharma.com/boards/sho...d.php?t=545725


      "The National Meeting Video. What is that gonna look like? Any thoughts?"

      "Hmmm good call. I think David Wilk comes on stage with a line like "Where'd everybody go" The lights dim. Fade to video. I picture some type of man made tough mudded obstacle course where various home office personnel hop out of the mud in slow mo and runs to the finish line which is shaped like a Galderma G. After high fiving each other several dozen times they turn to the camera, flex their biceps, and in unison shout, "Galderma, Only the Strong Survive"

      "I think this year's video is all in the editing. They will have a clip of FH pumping up the crowd, then cut to a Traverse getting towed. Have Dr. B talking about the psychosocial impact of Rosacea, then cut to a screaming rebound patient. A scene from camp wonder, then a scene of a former IC winner on the unemployment line. Whatever it looks like I can assure you three things - a massive production budget, bad acting, and a video that goes right to the trash. But people will applaud out of fear."

      "Too predictable. We are going for gold etc! You're not a bronze or silver medal rep, no, you are golden! Quick show some motivational clip from unexpected athletes winning gold. An underhanded insult. Have a former Olympic gold medal skier give a speech on a recorded video. So touching "team Galderma!"
      All a fraud..."

      Oh My.. they're a bit cranky about the company down there at Galderma. Cranky but accurately funny. It's so sad for their families though. They are getting hit hard right at the holiday season.

      Comment


      • Sorry

        Sorry i m new

        What do you for s'endormir mp please?

        Comment


        • Originally posted by Victime roac View Post
          Sorry i m new

          What do you for s'endormir mp please?
          This usually works ~~> la réveiller

          Comment


          • Originally posted by Makron View Post
            "Buggers, the Galderma forum moderators showed up at work today and probably saw the carnage their reps caused at the Pharma Cafe forum and deleted all the compromising (for Mirvaso) posts"

            Why would they do that. There is nothing wrong with Mirvaso. It is working fine and it will be approved in the rest of the world soon. There is nothing to indicate that there is any major issues beyond thsoe found in the trials. No postmarketing adverse effects have been listed by or forwarded to the FDA. When you search Mirvaso you get nothing. No significant amount of complaints have been forwarded to Galderma either. Storys on this forum are just that, storys or misuse and allergic reactions at best. The only people you can verify are the ones positive to Mirvaso. Everything is fine. Just relax and stop trolling the pharma forum. That is not nice.
            Wow
            Tell us, what's your interest in Mirvaso? Why are you defending it so strongly? Are you going to/did you try it?

            Comment


            • Update on Anecdotal Reports

              12 Positive
              39 Negative
              1 Ambiguous
              2 News Blurbs
              Brady Barrows
              Blog - Join the RRDi


              Comment


              • Starlite,

                Found another TV news blurb that doesn't quite follow the pattern, but is close, Meg Farris of WWLTV in New Orleans reports about rosacea and the new FDA approved Mirvaso, interviews a physician, Mary Lupo, MD, of New Orleans, but does not name the patient who is shown using Mirvaso in front of a mirror. Can't use it as a positive user experience since no name is listed for the patient.

                http://www.wwltv.com/news/health/Doc...228237401.html

                So apparently, each TV station has some latitude in how they report this 'new FDA approved treatment for rosacea.' We will without a doubt find more of these reports.
                Brady Barrows
                Blog - Join the RRDi


                Comment


                • Originally posted by Brady Barrows View Post
                  12 Positive
                  39 Negative
                  1 Ambiguous
                  2 News Blurbs
                  Did you also include Darren1980's positive review (for now at least) in the list Brady?
                  It's here: http://www.rosaceagroup.org/The_Rosa...eriences/page6
                  My rosacea related blog: http://scarletnat.blogspot.com/2012/...edication.html

                  Comment


                  • Originally posted by nat007 View Post
                    Did you also include Darren1980's positive review (for now at least) in the list Brady?
                    It's here: http://www.rosaceagroup.org/The_Rosa...eriences/page6
                    Yes, indeed. Way ahead of you. Also found #13 Jordan's positive review of Mirvaso.
                    Brady Barrows
                    Blog - Join the RRDi


                    Comment


                    • Yes reading your updated list now Brady
                      Its there with some other positives, good detective work again.
                      My rosacea related blog: http://scarletnat.blogspot.com/2012/...edication.html

                      Comment


                      • ?

                        August 2010 forum post by nat007: Have ordered brimonidine powder from a Chinese manufacturer. My skin doesn't tolerate the brimonidine eye gel, so I now go for the pure and active ingredient and will mix it myself with water and apply to the rosacea skin.

                        September 2010 forum post by nat007: A friend has a very precise measuring thing, to my suprise (for honey actually) and I have been able to measure 0,2 g. I have put it in 100 ml of bottled water, all things first sterilized in boiling water. And I have patted the solution on my chin and part of my right cheek AND make pictures of the skin, so perhaps I can detect pale skin in some time.

                        Your wrote this on your blog for 2010: I mixed the brimonidine powder with some water and applied it to my cheeks. (Or to be more precise, I discussed with my pharmacist for some time about the exact dose and mixing of the exact amount of brimonidine mcg with the exact amount of water, to get the same percentage mix as Mirvaso has of brimonidine versus carrier base, in my case water, in Mirvaso's case a enutral gel).


                        DOSAGE FORMS AND STRENGTHS
                        MIRVASO (brimonidine) topical gel, 0.33% is a white to light yellow opaque aqueous gel. Each gram of gel contains 5 mg of
                        brimonidine tartrate, equivalent to 3.3 mg of brimonidine free base.


                        What is this. The part in red was not there Before when I saw your blog some time ago. You added that after the original post and it makes no sense. The dose you say you used in the forum is not the one that is used in Mirvaso and why would you apply brimonidine on your skin if you knew that you did not tolerate it?

                        Comment


                        • Originally posted by Makron View Post
                          August 2010 forum post by nat007: Have ordered brimonidine powder from a Chinese manufacturer. My skin doesn't tolerate the brimonidine eye gel, so I now go for the pure and active ingredient and will mix it myself with water and apply to the rosacea skin.

                          September 2010 forum post by nat007: A friend has a very precise measuring thing, to my suprise (for honey actually) and I have been able to measure 0,2 g. I have put it in 100 ml of bottled water, all things first sterilized in boiling water. And I have patted the solution on my chin and part of my right cheek AND make pictures of the skin, so perhaps I can detect pale skin in some time.

                          Your wrote this on your blog for 2010: I mixed the brimonidine powder with some water and applied it to my cheeks. (Or to be more precise, I discussed with my pharmacist for some time about the exact dose and mixing of the exact amount of brimonidine mcg with the exact amount of water, to get the same percentage mix as Mirvaso has of brimonidine versus carrier base, in my case water, in Mirvaso's case a enutral gel).


                          DOSAGE FORMS AND STRENGTHS
                          MIRVASO (brimonidine) topical gel, 0.33% is a white to light yellow opaque aqueous gel. Each gram of gel contains 5 mg of
                          brimonidine tartrate, equivalent to 3.3 mg of brimonidine free base.


                          What is this. The part in red was not there Before when I saw your blog some time ago. You added that after the original post and it makes no sense. The dose you say you used in the forum is not the one that is used in Mirvaso and why would you apply brimonidine on your skin if you knew that you did not tolerate it?

                          I called and discussed with my pharmacist at the time how to make a similar mix. We made it first with 0,2 mcg, or 2 mg. Must have made an error in the mcg/mg/gr in the original forum post in 2010, but that's in writing, not when I actually measured it off with the pharmacist on the phone. We tried 2 mg first, to not make it too strong, I later made a second bash with 3 mg.

                          First time trying I didn't know if I would tolerate it or not, would I? The eye gel had preservatives in it and I can't use anything on my skin. I don't moisturize apart from some jojoba oil of late, for the past few months. But nothing for the 8 years before it, just bottled water. So when I did a test patch with the brimonidine eye gel, like my friend Wrincleclue used (and posted on, initially with good success), it burned and turned red, but not after 5 hours; immediately. Discussed it with pharmacist, assumed it was as such not a good trial, as this brimonidine eye gel brought too many variables with the inactive ingredients of the eye gel, and I made the mix with water and brimonidine powder only then, to give it a fair try. In hindsight I should have used it only on a part of my skin instead of putting it all over my face, but I wanted to do a proper test and make some reliable pictures. As I wrote in more recent posts here at the beginning of this thread(s) (and I am flattered you are spitting through all of them), I probably used too much of it. It took some time for the paleness and light patches to set in and I put a second layer of the mix on in the mean time. And then some more when I felt the mix was wearing off and burning red patches were coming through. As you can read, I wrote that my brimonidine experience was most likely not fully comparable to Mirvaso, as I might have used too much of it (defo not a pea sized drop) and that I hoped Mirvaso would work better. But I did warn people of the bad rebound people like me and Wrincleclue and Mistica experienced while experimenting with brimonidine. Flaws in the execution style taken into consideration.

                          The red adding to the blog was made yesterday, because I read it back and in my old blog posts (had another blog before this one, dating from 2007-2011 approx.) I had mentioned the pharmacist discussion there and in the new one I had condensed the diary entries and left some of these details out. Reading it back yesterday, it seemed incomplete, and as you can read back on the forum posts from 2010, I mentioned these added details there as well.

                          Not really sure what you are trying to say with this summary; that I used 2 mg instead of the 3,3 that Mirvaso consists of? That I update a blog post with details that were also used in the original forum post? That I duped Mirvaso based on a shaky brimonidine trial? As you can read back, I knew and stated that you can't compare the home made brimonidine trial with an end product like Mirvaso. But the brimonidine rebound effect which a lot of people experience here was a right estimation and prediction as it looks now, wasn't it?

                          And now its time to say who you are. new time poster, appearing at the first Mirvaso review posts here and noticing an update I made less than 24 hours ago. Doubt your such a fan of the blog.
                          Last edited by nat007; 9 December 2013, 11:51 PM.
                          My rosacea related blog: http://scarletnat.blogspot.com/2012/...edication.html

                          Comment


                          • Found another news blurb just like the previous post #1042

                            KTVI TV news blurb, September 24, 2013, by Randi Naughton, interviews Madhavi Kandula, MD:

                            http://fox2now.com/2...ved-by-the-fda/

                            similar to post #1042 and used the same stock footage
                            Brady Barrows
                            Blog - Join the RRDi


                            Comment


                            • Makron: Here is more of what was written at the time: http://www.rosaceagroup.org/The_Rosa...monidine/page8

                              18th August 2010 10:40 AM: "I tried brimonidine also several days, after dear Wrincleclue helped me get some, and my chin was clearly paler after use. Next day some on the cheek, and I did see a lighter skin tone, but... also a rash after some time. Rough skin, so to speak and burning a bit. So my theory is, that the brimonidine is working but the preservative and alcohols that are added to the opthalmic solution are too much for my paper thin skin. So, tried to order some pure brimonidine powder from the pharmacist, but available.... Probably because the pharmaceuticals (Falcon in this case) won't give away the active ingrediënt. So I googled and foudn some suppliers in China (..). Emailed some of them and the problem now is that they send it in a big dose, minimum of 100 g. mostly (which costs about 800 US dollars!!) and I could get 5 g. from one supplier, for 200 US dollars. Now, I am a big dumbo with those measuring quantities. What do you guys think? It seemed very little to me, 5 g, but then I saw the solution and it only has 0,2% brimonidine in it. Sp p[erhaps 5 g is quite a lot actually then?
                              I discussed it with the pharmacist and he said that he can either put the powder in a cream or gel for me, or I can mix it myself daily with water, so we don't need a preservative. I will have to find out how much powder exactely I can use in a drop of water, don't want it to be too much...
                              What do you guys think? These Chinese factories supply the product to the big pharmaceuticals, so I hope it is safe. What about the price? Seems very high to me, but I don't know how much we would need for daily use? And perhaps there are more people interested in this and want to join in?"


                              Then 2nd September 2010 05:05 PM: "Ok, the brimonidine powder arrived! Just a small sealed see through bag with whit´ish powder in it. Did email the Chinese woman again to stress again how important it is to have proper brimonidine so I can truelly give it a try and perhaps pass the company details on if it works, so I guess it´s a matter of trust now, and perhaps even white skin!
                              A friend has a very precise measuring thing, to my suprise (for honey actually) and I have been able to measure 0,2 g. I have put it in 100 ml of bottled water, all things first sterilized in boiling water. And I have patted the solution on my chin and part of my right cheek AND make pictures of the skin, so perhaps I can detect pale skin in some time.
                              The skin is feeling a bit tingling and numb´ish now, not really numb but it feels a little bit different then the other skin. No burning though, nothing uncomfortable. I am a little bit afraid it will do nothing and I just threw away 200 dollars...
                              To be continued...


                              2nd September 2010 09:12 PM: So far so good. I put the brimonidine solution on my lower left cheek and chin and within time white patches showed. I have put more of the solution on the spaces in between and it´s still patchy, but def. very pale patches. Chin is completely pale now and left lower cheek has very clear patches. My skin seems to handle it, although it feels ´tight´ and a bit numb at the same time and can tingle. It´s weird, not painful. I am aware of the feeling of the skin, unlike other normal skin. But nothing too bad. Have to see now if the dreaded rebound flare comes.
                              Does anyone have an idea how I can avoid the patches and just have even pale skin???
                              Will mail Tony Chu as well about it, I know he´s interested in this and perhaps he also (like my pharmacist on the phone) has an idea about the percentage and solution. I don´t understand why it shows in patches.....To be continued..


                              2nd September 2010 10:39 PM: Ai ai ai, this is looking promising! I´m not easily positive when it comes to rosacea, but my cheek (I wrote left cheek, but just realized that´s on my pictures, its actually my right, detail) is PALE. Stays like that when facing a trigger (and the other one does flare up).The patchyness is still there but seems to fill up a bit and the difference is quite dramatic I think. Skin feels still a little bit tight but that´s about it. Note that my upper skin is paper thin and always irritated and dry, so I expected more troubles from it. I just can´t believe this, and am sort of waiting for the disappointment to throw me back in reality. Will see how the cheek is tomorrow morning and if still good, will put the solution on both cheeks then.
                              Just thin from what I understood this brimonidine is the active ingredient also in the upcoming Sansrosa cream. But wouldn´t it be much better for rosaceans to mix the active ingredient themselves into either water or their own cream? I am almost certain there will be some kind of alcohol or preservative in that cream. This way we have the pure active ingredient and almost no irritants to the skin.
                              Thanks Wrincledclue for suggesting the brimonidine eyedrops!!!!


                              3rd September 2010 10:13 AM: this morning still pale on the treated area´s, the rest moderately flushed.
                              So far no other side effects. I called the pharmacist to ask how I can store the solution. I first desinfected the weighting scale and measuring cup in boiling water and used bottled water from a sealed bottle by the way, just to be on the safe side.
                              He said that it can be stored in the fridge, to preserve it longer. The molecules of brimonidine are small he said and it´s very solutable to water, so he doesn´t expect christals to be formed in the fridge. I put the solution straight on my face. I put some of the liquid in a little cup and put it on my skin with my finger, as much as needed and I also ´paint´ more on the patches that are blotchy. Not sure if this is too much though, as it´s the strength of the normal eye drop solution, but it´s been working.. I have ordered the 5 g sample here:
                              sales6@sinochem-nanjing.com
                              Miss Fairy Yang
                              The corporation is Sinochem Nanjing,
                              website: http://www.sinochem-nanjing.com/

                              3rd September 2010 08:32 PM : Very bad rebound in right cheek. Left one is fine for some reason. The right cheek has already a red patch this morning but now it´s full blown all over the cheek, haven´t had it this bad in a long time. Not sure if it is brimonidine related, did have some irritation from indirect sunlight earlier this week, but this is really full force flushing. Will give my skin some days to calm down again and see again.

                              4th September 2010 10:58 AM: Big flare on the left cheek as well this morning. Am having two red flushed cheeks again. Am sure now that it has to do with the after effect of the brimonidine, as the left cheek was not too bad before I put brim. on it. Have to sit it out now and see how long it takes for the skin to settle again. Big bummer, as I was over the moon with my pale complexion. But if this is the standard, then the flare ups might not be worth the positive effects perhaps. Although it might also be an option to keep using the brimonidine solution every other 8-10 hours and be a step ahead of rebound flushing. The thing is though, that I am not yet certain if this stuff can cause long term damage or alterations to the facial blood vessels and I don't want to risk anything here. But the test is completed for now, it works and it has after effects. I am sad that I have to go through the busy weekend looking like this and feeling burned up, and more sad that I can;'t put the brimonidine on my face at the moment, but well. Is there anyone with suggestions perhaps? It works, but why do I (others) get rebound flushing? It can't be the inactive ingredients, as there are none in my case. I would love to use this daily but am not convinced I am not making matters worse in the long run with it.

                              Then note the responses from other forum users, including our highly valued moderator Melissa W at #113, who echoed this same experience.

                              4th September 2010 10:07 PM: Thanks guys. I think the worst is already over, flushing wise. Still redness on mostly one cheek, but clear patches of skin are showing already in between and the full force flushing seems over. So I think the flushing reaction is about 8 hours or something. Perhaps about as long as the paleness reaction is, so that´s not a good thing. Don´t know either Melissa why some , like WC, are not having the rebound flushing. I do have to admit that I used the solution (similar to 0,2%) very generously on my face, and didn´t use the 2 drops, but more. So that might have added to the reaction afterwards. But only afterwards, not during the 8/10 hours of action, then I was very pale. Qustions indeed. Will wait till skin is back to its old self and try again in time, as I am very impressed with how it works. Just don´t know why this rebound flushing is happening. Will try different amounts in the near future.

                              These different amounts, 3 mg, was used at another evening, not the same first evening, I mixed that one up in my former post, its been a good few years.
                              My rosacea related blog: http://scarletnat.blogspot.com/2012/...edication.html

                              Comment


                              • "Or to be more precise, I discussed with my pharmacist for some time about the exact dose and mixing of the exact amount of brimonidine mcg with the exact amount of water, to get the same percentage mix as Mirvaso has of brimonidine versus carrier base, in my case water, in Mirvaso's case a enutral gel)"


                                This is what you added. This was not there before. You claim you did this in 2010. You tried to get the exakt same percentage as Mirvaso?.


                                Mirvaso info: "Each gram of MIRVASO (brimonidine) topical gel, 0.33% contains 5 mg of the active ingredient brimonidine tartrate (equivalent to 3.3 mg of brimonidine free base)" Not sure whats the difference between brimonidine 'free base' and 'active ingredient' and in what category the pure powder falls?

                                You dont even understand the mirvaso dosage from your post in 2013 and you where making the exakt same mix in 2010. lol


                                "Must have made an error in the mcg/mg/gr in the original forum post in 2010, but that's in writing, not when I actually measured it off with the pharmacist on the phone. We tried 2 mg first, to not make it too strong, I later made a second bash with 3 mg."

                                oh really?. You never stated anything about 3 mg until mirvaso was released and even then you did not understand ther mirvaso dosage. Why is Mirvaso even a topic on your blog. Remove that please. Your self tests have nothing to do with mirvaso. You probably lied about the dosage or in a best case scenario you


                                "I knew and stated that you can't compare the home made brimonidine trial with an end product like Mirvaso. But the brimonidine rebound effect which a lot of people experience here was a right estimation and prediction as it looks now, wasn't it?"

                                You getting rebound when you already did not tolerate the eye drops using a home made brew with ingridients from a chinese dealer is not the right estimation for anything. Why is Mirvaso even a topic on your blog. You do not state that home made trial is not comperable with mirvaso in your blog. The one with the head title "Mirvaso; The brimonidine trial: it was not what I had hoped ..." Remove that please or make that statement. Your self tests have nothing to do with mirvaso. You probably li.ed about the dosage or in a best case scenario you forgot to mention something.

                                There is no such thing "as it looks now". The way it looks now is that everything is fine with all verifiable sorces and there are some negative storys on a forum that cant be verified.

                                Comment

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