Mirvaso has been approved by the FDA.

[Starlite]

Don't tell me you were going to agree with me ;)

One more thing to realise as well, the trialists were clinically assessed as well as patient assessed. So their participation will have an idea of how well it is working or not by someone else who has the ability to confirm the results or bad reaction.

What if blushers should not use Mirvaso ? What if it is really is only for those with a permanent red face ? Galderma hasn't said that, but it is worth considering.

Maybe, maybe not.

Let me just say that none of us, not you, not me, none of us.... are "selection bias" free. Human beings will always have as part of their experience, subjective perceptions. Even "scientists" who try their best to set up objective conditions for trials and experiments have their biases that affect out comes.

The lens that *I* use to look at this issue is colored by a lot of research and I have developed a "cynical and jaded" view of the state of main stream medicine. If you just look at the tobacco company tale through the years and how they claimed one thing, and so did the Docs and the FDA until the evidence gathered, the pain and suffering mounted, the whistle blowers finally hit critical mass, and their castle of lies finally collapsed. If you are 30 or under you won't have that history burned in your mind. If you are closer to 60, like I am, you will remember that there was a time when cigarets, asbestos, and DDT were all sanctioned and guaranteed safe by all the experts. I am sure not all of those sanctioning these things were in on a "conspiracy" Far from it.. most of them were well meaning individuals who were only going off of what they had been told. There were just a few greedy scoundrels at the top who knew the depth of the lies. However even among them, the lies only started after a new and exciting product had been discovered to be harmful and they made a choice to hide that. Money and power has a tendency to be very addicting. When faced with the possible loss of all that, do you even know what you would do at that moment?

Black and white is the worst place to stand on all of this. Just know that these companies are in it for profit and gain, not your well being. If we are smart consumers then they have no choice but to give us a better quality product. What we are seeing here in terms of number of people who report having tried the product vs the number of people who report (notice I was careful to use the word report) adverse out comes is not good. This is not looking good. It's still to early to make any conclusions about that yet simply because of that lovely "selection bias" issue impacting who might sign up for a forum and report to us vs who had a happy experience and never thought to seek out a forum of people to commiserate with. Those people are not motivated to report anything. They are just happy! The fact still remains that many people who have gathered here are not doing well after using Mirvosa and being a wise consumer requires us to advise people to go very slow and test this for themselves so they don't become injured.

There are a lot of people who would beat a path to the door of any company who helped people with rosacea get well and they would bring loads of cash with them. That's the proper aim of any pharma company. Hold them to that standard.

[johnabetts]

If this resignation is due to the potential failure of their new product on the marketplace then equally guilty is the FDA who gave their approval.

[Mirvaso2013]

Don't tell me you were going to agree with me ;)

One more thing to realise as well, the trialists were clinically assessed as well as patient assessed. So their participation will have an idea of how well it is working or not by someone else who has the ability to confirm the results or bad reaction.

What if blushers should not use Mirvaso ? What if it is really is only for those with a permanent red face ? Galderma hasn't said that, but it is worth considering.

Have you not being reading this thread ?

We have had those people on this thread who used Mirvaso and it made them Flush ..

In most cases these people never Flushed before

[Mirvaso2013]

If this resignation is due to the potential failure of their new product on the marketplace then equally guilty is the FDA who gave their approval.

I am a great believer in Karma .

And those people who are responsible for Mirvaso being approved will get everything that's coming to them .

[nat007]

Lying son of a bitch ... that's what he is

So the **** has hit the fan about Mirvaso .


And I see we got a mention in the article above

In the article:

"But since the product’s release, results have been mixed. Online rosacea message boards have roundly attacked the product, saying that the rebound flushing caused by the drug was worse than the initial redness itself."


WOWWW thank you guys!!! That is great, for a change, that journalists picked up on it. Thanks for posting and posting your REAL experiences here and under the Mirvaso video's and articles, for this "wonder drug" and "solution" for rosacea (shakes head). More like the equivalent of steroid cream in terms of worsening and rebound if you ask me. Keep the real reviews coming guys.

[Mirvaso2013]

In the article:

"But since the product’s release, results have been mixed. Online rosacea message boards have roundly attacked the product, saying that the rebound flushing caused by the drug was worse than the initial redness itself."


WOWWW thank you guys!!! That is great, for a change, that journalists picked up on it. Thanks for posting and posting your REAL experiences here and under the Mirvaso video's and articles, for this "wonder drug" and "solution" for rosacea (shakes head). More like the equivalent of steroid cream in terms of worsening and rebound if you ask me. Keep the real reviews coming guys.

Agreed .

And where are these people who took part in the Trials . Please Come forward

[nat007]

Don't tell me you were going to agree with me ;)

One more thing to realise as well, the trialists were clinically assessed as well as patient assessed. So their participation will have an idea of how well it is working or not by someone else who has the ability to confirm the results or bad reaction.

What if blushers should not use Mirvaso ? What if it is really is only for those with a permanent red face ? Galderma hasn't said that, but it is worth considering.

Ok David, I think you make good points, but did you watch that video on the last page? If that is an official Mirvaso (mirvosa w/e) instruction viceo, including a MD and a patient, and that is the amount of redness their test people had, than the whole trial was a joke imo. "You can see her redness", NO I DON'T. Perfectly normal skin. Why didn't they use the severe patients in this video of which the Galderma president was writing? Who knows if that whole test panel of what, 300 patients? all looked like her? Diagnosed or not, that would seriously influence the outcome, as most trouble is encountered by those with a bit more serious redness and flushing. They could have at least make this woman flush before starting the camera.....




Ok I also posted below this article, maybe other people who actually tried the mirvaso will want to do as well? Seems the only channel to reach them at this point:

http://healthcare.dmagazine.com/2013/10/15/francois-fournier-out-as-galderma-u-s-a-president/

[David Pascoe]

Ok David, I think you make good points, but did you watch that video on the last page? If that is an official Mirvaso (mirvosa w/e) instruction viceo, including a MD and a patient, and that is the amount of redness their test people had, than the whole trial was a joke imo. "You can see her redness", NO I DON'T. Perfectly normal skin. Why didn't they use the severe patients in this video of which the Galderma president was writing?

I hear you but don't forget that in the clinical trials, for Mirvaso to be considered a success they noted a 2 grade improvement in the patient and clinician assessment of redness.

So there would have had to been some decent permanent redness before and a significant improvement after usage.

The scale goes to 5 and the baseline needed to be moderate or severe as scored both by patient and clinician.

So the official trials are telling us how they measured the success of Mirvaso.

Why we are not hearing from these sorts of users we can only guess.

[Makron]

Mirvaso

The people complaining about flushing have used Mirvaso for a week or less. The trials tested people during a year. That is something worth keeping in mind. I have eczema and I was prescribed protopic for it. When I first started using protopic my skin got worse the first 2-3 days and after that it just kept getting better until it leveled out at wich point I had a significant improvement in regard to the baseline. You people have to keep in mind that Mirvaso is a powerful topical otherwise it would not be on prescription so of course the skin is going to react initially but that will subside with continuous use. Put mirvaso on a healthy face and the skin would also react to it until it gets aclimated to it.

[red11]

The people complaining about flushing have used Mirvaso for a week or less. The trials tested people during a year. That is something worth keeping in mind. I have eczema and I was prescribed protopic for it. When I first started using protopic my skin got worse the first 2-3 days and after that it just kept getting better until it leveled out at wich point I had a significant improvement in regard to the baseline. You people have to keep in mind that Mirvaso is a powerful topical otherwise it would not be on prescription so of course the skin is going to react initially but that will subside with continuous use. Put mirvaso on a healthy face and the skin would also react to it until it gets aclimated to it.

Well said, this stuff needs a chance before everyone slates it straight away, I don't believe the FDA would approve this without seeing good results.

[Mirvaso2013]

The people complaining about flushing have used Mirvaso for a week or less. The trials tested people during a year. That is something worth keeping in mind. I have eczema and I was prescribed protopic for it. When I first started using protopic my skin got worse the first 2-3 days and after that it just kept getting better until it leveled out at wich point I had a significant improvement in regard to the baseline. You people have to keep in mind that Mirvaso is a powerful topical otherwise it would not be on prescription so of course the skin is going to react initially but that will subside with continuous use. Put mirvaso on a healthy face and the skin would also react to it until it gets aclimated to it.

First post and you are defending Mirvaso .. very interesting

[wiry]

The people complaining about flushing have used Mirvaso for a week or less. The trials tested people during a year. That is something worth keeping in mind. I have eczema and I was prescribed protopic for it. When I first started using protopic my skin got worse the first 2-3 days and after that it just kept getting better until it leveled out at wich point I had a significant improvement in regard to the baseline. You people have to keep in mind that Mirvaso is a powerful topical otherwise it would not be on prescription so of course the skin is going to react initially but that will subside with continuous use. Put mirvaso on a healthy face and the skin would also react to it until it gets aclimated to it.

Maybe, but I think that is a very questionable approach.

- There are users that have used this for an extended amount of time. They had access to the active ingredient long before Mirvaso was released. The ones who use it longer seem to have the worst rebounds. Some are horrific!

- After a while, the drug starts losing effectiveness. I noticed that the same amount was becoming less and less effective. The rebound was essentially "pushing through" and nothing was going to stop that.

- In general, rosaceans are taught to NOT push through problems when trying new products. This approach has been disastrous for some and even causes rosacea in some people.

So what you are saying is questionable and does not consider the current knowledge and experience of others. I certainly would not do that.

[nat007]

Quote Originally Posted by Makron View Post
The people complaining about flushing have used Mirvaso for a week or less. The trials tested people during a year. That is something worth keeping in mind. I have eczema and I was prescribed protopic for it. When I first started using protopic my skin got worse the first 2-3 days and after that it just kept getting better until it leveled out at wich point I had a significant improvement in regard to the baseline. You people have to keep in mind that Mirvaso is a powerful topical otherwise it would not be on prescription so of course the skin is going to react initially but that will subside with continuous use. Put mirvaso on a healthy face and the skin would also react to it until it gets aclimated to it.

First post and you are defending Mirvaso .. very interesting

Yeh, very interesting indeed. Listen, they said the same about steroid cream, or accutane; just keep using it, go through the initial rebound, it gets worse before it gets better. Well surprise, for some it gets worse, and worse and worse and worse. A doctor I spoke to said the chemical rebound of Mirvaso is comparable to steroid use on rosacea skin; I doubt anyone would gamble with their faces in order to 'give Mirvaso a fair trial'. No offense but first time posters, without pictures, or any evidence they even have rosacea themselves or tried the Mirvaso can shout all they want but it makes zero impact, sorry to say..

[Mirvaso2013]

Mirvaso

This is after turning into some nightmare

Weve all been waiting 8 years for this release


Galderma you are a waste of space .

Shame on you for getting peoples hopes up and for also making them suffer the consequences

[alyfpet]

permanent damage

Well said, this stuff needs a chance before everyone slates it straight away, I don't believe the FDA would approve this without seeing good results.

Isn't the fact that people are using it and posting their results giving it a chance? What benefit would anyone have to have good results and then post bad results? I don't understand the logic. We all want so badly to better manage our rosacea that if something worked well, we would be singing from the rooftops, I would think.

I gave Mirvaso a chance, and now I wish to God that I had waited and read other peoples' results before trying it.

After 3 1/2 weeks, I am coming to accept that my baseline condition is worse off, but I still cry over this every day. My redness is worse, and my skin is puffy and inflamed in places where I had no problem before. When I flush now, my skin feels so tight that it feels like I am wearing a mask. I never had that before. It is very difficult functioning at work like this, let alone enjoying life in any sense.

I am sure, at this point, that my extreme and prolonged flushing resulted in new blood vessel growth. There is no other explanation that I can make sense of.