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  • nat007
    replied
    Originally posted by Makron View Post
    August 2010 forum post by nat007: Have ordered brimonidine powder from a Chinese manufacturer. My skin doesn't tolerate the brimonidine eye gel, so I now go for the pure and active ingredient and will mix it myself with water and apply to the rosacea skin.

    September 2010 forum post by nat007: A friend has a very precise measuring thing, to my suprise (for honey actually) and I have been able to measure 0,2 g. I have put it in 100 ml of bottled water, all things first sterilized in boiling water. And I have patted the solution on my chin and part of my right cheek AND make pictures of the skin, so perhaps I can detect pale skin in some time.

    Your wrote this on your blog for 2010: I mixed the brimonidine powder with some water and applied it to my cheeks. (Or to be more precise, I discussed with my pharmacist for some time about the exact dose and mixing of the exact amount of brimonidine mcg with the exact amount of water, to get the same percentage mix as Mirvaso has of brimonidine versus carrier base, in my case water, in Mirvaso's case a enutral gel).


    DOSAGE FORMS AND STRENGTHS
    MIRVASO (brimonidine) topical gel, 0.33% is a white to light yellow opaque aqueous gel. Each gram of gel contains 5 mg of
    brimonidine tartrate, equivalent to 3.3 mg of brimonidine free base.


    What is this. The part in red was not there Before when I saw your blog some time ago. You added that after the original post and it makes no sense. The dose you say you used in the forum is not the one that is used in Mirvaso and why would you apply brimonidine on your skin if you knew that you did not tolerate it?

    I called and discussed with my pharmacist at the time how to make a similar mix. We made it first with 0,2 mcg, or 2 mg. Must have made an error in the mcg/mg/gr in the original forum post in 2010, but that's in writing, not when I actually measured it off with the pharmacist on the phone. We tried 2 mg first, to not make it too strong, I later made a second bash with 3 mg.

    First time trying I didn't know if I would tolerate it or not, would I? The eye gel had preservatives in it and I can't use anything on my skin. I don't moisturize apart from some jojoba oil of late, for the past few months. But nothing for the 8 years before it, just bottled water. So when I did a test patch with the brimonidine eye gel, like my friend Wrincleclue used (and posted on, initially with good success), it burned and turned red, but not after 5 hours; immediately. Discussed it with pharmacist, assumed it was as such not a good trial, as this brimonidine eye gel brought too many variables with the inactive ingredients of the eye gel, and I made the mix with water and brimonidine powder only then, to give it a fair try. In hindsight I should have used it only on a part of my skin instead of putting it all over my face, but I wanted to do a proper test and make some reliable pictures. As I wrote in more recent posts here at the beginning of this thread(s) (and I am flattered you are spitting through all of them), I probably used too much of it. It took some time for the paleness and light patches to set in and I put a second layer of the mix on in the mean time. And then some more when I felt the mix was wearing off and burning red patches were coming through. As you can read, I wrote that my brimonidine experience was most likely not fully comparable to Mirvaso, as I might have used too much of it (defo not a pea sized drop) and that I hoped Mirvaso would work better. But I did warn people of the bad rebound people like me and Wrincleclue and Mistica experienced while experimenting with brimonidine. Flaws in the execution style taken into consideration.

    The red adding to the blog was made yesterday, because I read it back and in my old blog posts (had another blog before this one, dating from 2007-2011 approx.) I had mentioned the pharmacist discussion there and in the new one I had condensed the diary entries and left some of these details out. Reading it back yesterday, it seemed incomplete, and as you can read back on the forum posts from 2010, I mentioned these added details there as well.

    Not really sure what you are trying to say with this summary; that I used 2 mg instead of the 3,3 that Mirvaso consists of? That I update a blog post with details that were also used in the original forum post? That I duped Mirvaso based on a shaky brimonidine trial? As you can read back, I knew and stated that you can't compare the home made brimonidine trial with an end product like Mirvaso. But the brimonidine rebound effect which a lot of people experience here was a right estimation and prediction as it looks now, wasn't it?

    And now its time to say who you are. new time poster, appearing at the first Mirvaso review posts here and noticing an update I made less than 24 hours ago. Doubt your such a fan of the blog.
    Last edited by nat007; 9 December 2013, 11:51 PM.

    Leave a comment:


  • Makron
    replied
    ?

    August 2010 forum post by nat007: Have ordered brimonidine powder from a Chinese manufacturer. My skin doesn't tolerate the brimonidine eye gel, so I now go for the pure and active ingredient and will mix it myself with water and apply to the rosacea skin.

    September 2010 forum post by nat007: A friend has a very precise measuring thing, to my suprise (for honey actually) and I have been able to measure 0,2 g. I have put it in 100 ml of bottled water, all things first sterilized in boiling water. And I have patted the solution on my chin and part of my right cheek AND make pictures of the skin, so perhaps I can detect pale skin in some time.

    Your wrote this on your blog for 2010: I mixed the brimonidine powder with some water and applied it to my cheeks. (Or to be more precise, I discussed with my pharmacist for some time about the exact dose and mixing of the exact amount of brimonidine mcg with the exact amount of water, to get the same percentage mix as Mirvaso has of brimonidine versus carrier base, in my case water, in Mirvaso's case a enutral gel).


    DOSAGE FORMS AND STRENGTHS
    MIRVASO (brimonidine) topical gel, 0.33% is a white to light yellow opaque aqueous gel. Each gram of gel contains 5 mg of
    brimonidine tartrate, equivalent to 3.3 mg of brimonidine free base.


    What is this. The part in red was not there Before when I saw your blog some time ago. You added that after the original post and it makes no sense. The dose you say you used in the forum is not the one that is used in Mirvaso and why would you apply brimonidine on your skin if you knew that you did not tolerate it?

    Leave a comment:


  • nat007
    replied
    Yes reading your updated list now Brady
    Its there with some other positives, good detective work again.

    Leave a comment:


  • Brady Barrows
    replied
    Originally posted by nat007 View Post
    Did you also include Darren1980's positive review (for now at least) in the list Brady?
    It's here: http://www.rosaceagroup.org/The_Rosa...eriences/page6
    Yes, indeed. Way ahead of you. Also found #13 Jordan's positive review of Mirvaso.

    Leave a comment:


  • nat007
    replied
    Originally posted by Brady Barrows View Post
    12 Positive
    39 Negative
    1 Ambiguous
    2 News Blurbs
    Did you also include Darren1980's positive review (for now at least) in the list Brady?
    It's here: http://www.rosaceagroup.org/The_Rosa...eriences/page6

    Leave a comment:


  • Brady Barrows
    replied
    Starlite,

    Found another TV news blurb that doesn't quite follow the pattern, but is close, Meg Farris of WWLTV in New Orleans reports about rosacea and the new FDA approved Mirvaso, interviews a physician, Mary Lupo, MD, of New Orleans, but does not name the patient who is shown using Mirvaso in front of a mirror. Can't use it as a positive user experience since no name is listed for the patient.



    So apparently, each TV station has some latitude in how they report this 'new FDA approved treatment for rosacea.' We will without a doubt find more of these reports.

    Leave a comment:


  • Brady Barrows
    replied
    Update on Anecdotal Reports

    12 Positive
    39 Negative
    1 Ambiguous
    2 News Blurbs

    Leave a comment:


  • carmk700
    replied
    Originally posted by Makron View Post
    "Buggers, the Galderma forum moderators showed up at work today and probably saw the carnage their reps caused at the Pharma Cafe forum and deleted all the compromising (for Mirvaso) posts"

    Why would they do that. There is nothing wrong with Mirvaso. It is working fine and it will be approved in the rest of the world soon. There is nothing to indicate that there is any major issues beyond thsoe found in the trials. No postmarketing adverse effects have been listed by or forwarded to the FDA. When you search Mirvaso you get nothing. No significant amount of complaints have been forwarded to Galderma either. Storys on this forum are just that, storys or misuse and allergic reactions at best. The only people you can verify are the ones positive to Mirvaso. Everything is fine. Just relax and stop trolling the pharma forum. That is not nice.
    Wow
    Tell us, what's your interest in Mirvaso? Why are you defending it so strongly? Are you going to/did you try it?

    Leave a comment:


  • Starlite
    replied
    Originally posted by Victime roac View Post
    Sorry i m new

    What do you for s'endormir mp please?
    This usually works ~~> la réveiller

    Leave a comment:


  • Victime roac
    replied
    Sorry

    Sorry i m new

    What do you for s'endormir mp please?

    Leave a comment:


  • Starlite
    replied
    Originally posted by nat007 View Post
    LOL, this is how Galderma's own think about such video presentations



    "The National Meeting Video. What is that gonna look like? Any thoughts?"

    "Hmmm good call. I think David Wilk comes on stage with a line like "Where'd everybody go" The lights dim. Fade to video. I picture some type of man made tough mudded obstacle course where various home office personnel hop out of the mud in slow mo and runs to the finish line which is shaped like a Galderma G. After high fiving each other several dozen times they turn to the camera, flex their biceps, and in unison shout, "Galderma, Only the Strong Survive"

    "I think this year's video is all in the editing. They will have a clip of FH pumping up the crowd, then cut to a Traverse getting towed. Have Dr. B talking about the psychosocial impact of Rosacea, then cut to a screaming rebound patient. A scene from camp wonder, then a scene of a former IC winner on the unemployment line. Whatever it looks like I can assure you three things - a massive production budget, bad acting, and a video that goes right to the trash. But people will applaud out of fear."

    "Too predictable. We are going for gold etc! You're not a bronze or silver medal rep, no, you are golden! Quick show some motivational clip from unexpected athletes winning gold. An underhanded insult. Have a former Olympic gold medal skier give a speech on a recorded video. So touching "team Galderma!"
    All a fraud..."

    Oh My.. they're a bit cranky about the company down there at Galderma. Cranky but accurately funny. It's so sad for their families though. They are getting hit hard right at the holiday season.

    Leave a comment:


  • nat007
    replied
    Originally posted by Brady Barrows View Post
    In searching for Mirvaso YouTube videos found this one, entitled 'Galderma'

    LOL, this is how Galderma's own think about such video presentations



    "The National Meeting Video. What is that gonna look like? Any thoughts?"

    "Hmmm good call. I think David Wilk comes on stage with a line like "Where'd everybody go" The lights dim. Fade to video. I picture some type of man made tough mudded obstacle course where various home office personnel hop out of the mud in slow mo and runs to the finish line which is shaped like a Galderma G. After high fiving each other several dozen times they turn to the camera, flex their biceps, and in unison shout, "Galderma, Only the Strong Survive"

    "I think this year's video is all in the editing. They will have a clip of FH pumping up the crowd, then cut to a Traverse getting towed. Have Dr. B talking about the psychosocial impact of Rosacea, then cut to a screaming rebound patient. A scene from camp wonder, then a scene of a former IC winner on the unemployment line. Whatever it looks like I can assure you three things - a massive production budget, bad acting, and a video that goes right to the trash. But people will applaud out of fear."

    "Too predictable. We are going for gold etc! You're not a bronze or silver medal rep, no, you are golden! Quick show some motivational clip from unexpected athletes winning gold. An underhanded insult. Have a former Olympic gold medal skier give a speech on a recorded video. So touching "team Galderma!"
    All a fraud..."

    Leave a comment:


  • Starlite
    replied
    Originally posted by roasceaclearwannabe View Post
    Don't think this article has been posted before:

    http://healthcare.dmagazine.com/2013...-galderma-usa/
    Oooooo no it has not been. Thanks.

    Leave a comment:


  • Starlite
    replied
    Originally posted by Makron View Post
    "Buggers, the Galderma forum moderators showed up at work today and probably saw the carnage their reps caused at the Pharma Cafe forum and deleted all the compromising (for Mirvaso) posts"

    Why would they do that. There is nothing wrong with Mirvaso. It is working fine and it will be approved in the rest of the world soon. There is nothing to indicate that there is any major issues beyond thsoe found in the trials. No postmarketing adverse effects have been listed by or forwarded to the FDA. When you search Mirvaso you get nothing. No significant amount of complaints have been forwarded to Galderma either. Storys on this forum are just that, storys or misuse and allergic reactions at best. The only people you can verify are the ones positive to Mirvaso. Everything is fine. Just relax and stop trolling the pharma forum. That is not nice.
    "Why would they do that?" You ask, as if it didn't happen. Nat has screen shots of many of the posts she has been talking about, that are no longer there. They did indeed do that. Why? Because they have something to hide.

    Profile of the Sociopath As I said.. sociopathic leadership and structure.

    *Manipulative and Conning
    They never recognize the rights of others and see their self-serving behaviors as permissible. They appear to be charming, yet are covertly hostile and domineering, seeing their victim as merely an instrument to be used. They may dominate and humiliate their victims.

    *Pathological Lying
    Has no problem lying coolly and easily and it is almost impossible for them to be truthful on a consistent basis. Can create, and get caught up in, a complex belief about their own powers and abilities. Extremely convincing and even able to pass lie detector tests.

    *Lack of Remorse, Shame or Guilt
    A deep seated rage, which is split off and repressed, is at their core. Does not see others around them as people, but only as targets and opportunities. Instead of friends, they have victims and accomplices who end up as victims. The end always justifies the means and they let nothing stand in their way.

    *Callousness/Lack of Empathy
    Unable to empathize with the pain of their victims, having only contempt for others' feelings of distress and readily taking advantage of them.

    *Irresponsibility/Unreliability
    Not concerned about wrecking others' lives and dreams. Oblivious or indifferent to the devastation they cause. Does not accept blame themselves, but blames others, even for acts they obviously committed.

    Leave a comment:


  • roasceaclearwannabe
    replied
    Don't think this article has been posted before:

    Breaking news, local reporting, and expert insights on the business of healthcare in Dallas and North Texas.

    Leave a comment:

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