Gallo's theory and resources

[Melissa W]

If you haven't already read the cpn links here I recommend it as it is fascinating reading. There is just too much researchers/scientists/doctors don't know.

btw When I increased my vit D intake to 8800 IU's a day which I am currently taking I noticed no adverse effects to my rosacea and in fact, (but I cannot be sure) I feel like I am flushing less.

[banshee]

I've only loosely been following the Vit D discussion, here and with people's supplementation, so can't claim to be speaking with a great deal of insight.

That said, I think I read someone brought up the sage point of there being a difference b/w synthetic D3 (which I understand is what Gallo used) and natural....I've never been on board with the cathelicidin is the culprit theory b/c while no doubt it is part of the problem, so are a million other substances which take part in the normal inflammatory process, particularly when it goes out of control.

So I think it's dangerous to block D3 receptors (please correct me if I'm wrong that's what Gallo is suggesting). Modern milk and dairy products, even some organic...the natural D has been destroyed in pasteurization and synthetic D is added back in.

When I take synthetic D3 vs. getting it from Cod Liver Oil (where again you must watch if it comes from the fish or is added back in), I observe my body behaves much differently. I'm anxious and my heart seems to be palpitating faster throughout the day which leads to more flushing.

Just a layman's observation that supplementing with natural or synthetic might account for folk's varying responses. Then again, I have not tried high dose natural D to test this theory and note how my flushing responds.

[rhad]

This is a very interesting thread. very interesting read too! If we could find the connection of where cathelicidin and Kallikrein begins in the metabolic cycle, or how it's regulated...that would be what we need.

It only takes 1 enzyme somewhere down the line of these two substances that affects it to stop working. 1 enzyme in metabolism stops functioning, it could cause all kinds of metabolic imblances in the body... This is one great thread that gives us a starting point where we can build from.

I appreciate the Efforts that were put into this thread, gathering all this useful information.

Thanks,

Rhad

[mrsmoof]

Email to Gallo...

I just sent the following email to Dr Gallo.. I will update if I receive a response.


Dr Gallo,

I suffer from Rosacea and am very interested in your research. I have a couple of questions for you:

1) There is great debate in Rosacea Forums concerning taking Vit D3 supplements and increasing your Vit D Levels to near 100. Some have claimed once they increased their Vit D levels to 100 and kept them at that level for a year or so their Rosacea symptoms started to disappear and certain triggers were not triggers anymore..... What are your thoughts about increasing your Vit D levels to near 100 and its possible effects on Rosacea? Could a study on mice be done where you increased their Vit D levels and see what reactions they have to the increases?

2) You mentioned in an interview "We have looked at the more upstream, earlier innate immune triggers and have found some very exciting abnormalities in patients that may explain why they are so sensitive to so many things in their environment." Can you discuss these exciting abnormalities and with these findings can this lead to a cure or better treatment of Rosacea for all subtypes?

Thank you for your time and thank you for all the research you are doing on Rosacea. Rosacea sufferers all over the world are very appreciative.

Regards,

[DukeCity]

Nice - THX

[mrsmoof]

I just hope he replies!

[mrsmoof]

Has anyone heard anything new from Gallo? I wish he would come out with something...

[mrsmoof]

Just an update.. I never have heard back from Dr Gallo and am guessing I never will.. That is too bad. I wish he would comment on his latest research.

[GJ]

To beguile the time while we wait, Mrsmoof, answer me this:

What do you call a man who used to walk around with a shovel on his head?

[mrsmoof]

To beguile the time while we wait, Mrsmoof, answer me this:

What do you call a man who used to walk around with a shovel on his head?

Answer: Doug

[maico11]

Requested Paper

Reddish, scaly, and itchy: how proteases and their inhibitors contribute to inflammatory skin diseases - Dr. Meyer−Hoffert.

This was requested, by I never saw a response.

[GJ]

Thankyou, Maico.
Doug: Doug, indeed,

[GJ]

Picked out of Warren's net. Another piece in the Gallo jigsaw. Hopefully the finished piece will be an image that can be made sense of. The suggestion here that overexpression of TLR2 is peculiar to rosacea is contradicted elsewhere. Some thoughts about too that tacrolimus (Protopic) is a TLR2 antagonist. Protopic, as we know, provides few miracles.
Toll like receptors are quite the fashion; many drugs being developed to specifically target them.

http://www.ncbi.nlm.nih.gov/pubmed/21107351?dopt=Abstract

Abstract

A diverse environment challenges skin to maintain temperature, hydration, and electrolyte balance while also maintaining normal immunological function. Rosacea is a common skin disease that manifests unique inflammatory responses to normal environmental stimuli. We hypothesized that abnormal function of innate immune pattern recognition could explain the enhanced sensitivity of patients with rosacea, and observed that the epidermis of patients with rosacea expressed higher amounts of Toll-like receptor 2 (TLR2) than normal patients. Increased expression of TLR2 was not seen in other inflammatory skin disorders such as atopic dermatitis or psoriasis. Overexpression of TLR2 on keratinocytes, treatment with TLR2 ligands, and analysis of TLR2-deficient mice resulted in a calcium-dependent release of kallikrein 5 from keratinocytes, a critical protease involved in the pathogenesis of rosacea. These observations show that abnormal TLR2 function may explain enhanced inflammatory responses to environmental stimuli and can act as a critical element in the pathogenesis of rosacea.Journal of Investigative Dermatology advance online publication, 25 November 2010; doi:10.1038/jid.2010.351.

[mrsmoof]

i wonder when we will hear from Dr Gallo again??

[GJ]

We just did, Doug.
Were you expecting a Christmas card?